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Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C–H Oxidative Addition

Tertiary benzylic stereocenters are accessed in high enantioselectivity by Ir-catalyzed branch selective addition of anilide ortho-C–H bonds across styrenes and α-olefins. Mechanistic studies indicate that the stereocenter generating step is reversible.

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Bibliographic Details
Published in:Journal of the American Chemical Society 2018-08, Vol.140 (30), p.9351-9356
Main Authors: Grélaud, Simon, Cooper, Phillippa, Feron, Lyman J, Bower, John F
Format: Article
Language:English
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Summary:Tertiary benzylic stereocenters are accessed in high enantioselectivity by Ir-catalyzed branch selective addition of anilide ortho-C–H bonds across styrenes and α-olefins. Mechanistic studies indicate that the stereocenter generating step is reversible.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.8b04627