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Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C–H Oxidative Addition
Tertiary benzylic stereocenters are accessed in high enantioselectivity by Ir-catalyzed branch selective addition of anilide ortho-C–H bonds across styrenes and α-olefins. Mechanistic studies indicate that the stereocenter generating step is reversible.
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Published in: | Journal of the American Chemical Society 2018-08, Vol.140 (30), p.9351-9356 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Tertiary benzylic stereocenters are accessed in high enantioselectivity by Ir-catalyzed branch selective addition of anilide ortho-C–H bonds across styrenes and α-olefins. Mechanistic studies indicate that the stereocenter generating step is reversible. |
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ISSN: | 0002-7863 1520-5126 |
DOI: | 10.1021/jacs.8b04627 |