Retinopathy of Prematurity Trends in Taiwan: A 10-Year Nationwide Population Study

To investigate the 10-year epidemiology and risk factors of retinopathy of prematurity (ROP) in Taiwan using the National Health Insurance Research Database. All premature infants (n = 34,192) from 2002 to 2011 were screened, and those with length of stay (LOS) longer than 28 days who survived after...

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Published in:Investigative ophthalmology & visual science 2018-07, Vol.59 (8), p.3599-3607
Main Authors: Kang, Eugene Yu-Chuan, Lien, Reyin, Wang, Nan-Kai, Lai, Chi-Chun, Chen, Kuan-Jen, Hwang, Yih-Shiou, Lin, Ciao-Ming, Wu, Wei-Chi, Hsu, Kuang-Hung
Format: Article
Language:English
Subjects:
Cross-Sectional Studies
Female
Follow-Up Studies
Forecasting
Gestational Age
Humans
Infant, Newborn
Male
Morbidity - trends
Population Surveillance - methods
Retinopathy of Prematurity - epidemiology
Retrospective Studies
Risk Factors
Taiwan - epidemiology
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Summary:To investigate the 10-year epidemiology and risk factors of retinopathy of prematurity (ROP) in Taiwan using the National Health Insurance Research Database. All premature infants (n = 34,192) from 2002 to 2011 were screened, and those with length of stay (LOS) longer than 28 days who survived after the initial discharge were enrolled (n = 11,180). The annual incidence of ROP and the risk factors associated with it were analyzed. A total of 4096 ROP infants, 36.6% of premature babies with LOS longer than 28 days, were identified. The numbers of newborns, premature infants, and cases with ROP decreased over time, but the proportion of extremely low birth weight infants increased over time (P < 0.01 for test of trend in number). Also, the proportion of ROP infants receiving treatment increased over time (P < 0.01 for test of trend in number). However, the incidence of ROP was steady throughout the study period. Multivariable analysis revealed that low birth weight, male sex (odds ratio [OR] = 1.12, P = 0.007), and multiparity (OR = 1.17, P = 0.002) were positively associated with ROP, whereas necrotizing enterocolitis (OR = 0.72, P = 0.002) had a negative association with ROP. The average incidence of ROP from 2002 to 2011 in Taiwan showed no significant change over the 10-year period. Proportion of treatment-requiring ROP increased. Low birth weight, multiparity, and male sex were independent risk factors of ROP.
ISSN:1552-5783
1552-5783
DOI:10.1167/iovs.18-24020