Near Infrared Light Triggered Cucurbit[7]uril-Stabilized Gold Nanostars as a Supramolecular Nanoplatform for Combination Treatment of Cancer

Developing a spatiotemporal-controlled platform with feasible synthesis and multifunctionality is highly desirable in the field of nanomedicine. Here, we present a near-infrared (NIR)-light-triggered approach to control the supramolecular assembly system for drug release and achieve synergistic chem...

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Bibliographic Details
Published in:Bioconjugate chemistry 2018-08, Vol.29 (8), p.2855-2866
Main Authors: Xu, Peng, Feng, Qishuai, Yang, Xiran, Liu, Simin, Xu, Chang, Huang, Liqun, Chen, Mengwei, Liang, Feng, Cheng, Yu
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacokinetics
Antineoplastic Agents - therapeutic use
Assembly
Bridged-Ring Compounds - chemistry
Bridged-Ring Compounds - therapeutic use
Camptothecin
Camptothecin - chemistry
Camptothecin - pharmacokinetics
Camptothecin - therapeutic use
Cancer
Chemotherapy
Combined Modality Therapy
Drug delivery systems
Gold
Gold - chemistry
Humans
Hyperthermia, Induced - methods
Imidazoles - chemistry
Imidazoles - therapeutic use
Infrared radiation
Infrared Rays
Irradiation
Light irradiation
MCF-7 Cells
Medical treatment
Mice
Microscopy, Confocal
Microscopy, Electron, Transmission
Nanostructures - chemistry
Nanotechnology
Neoplasms - drug therapy
Neoplasms - therapy
Organic chemistry
Photochemotherapy - methods
Radiation
Remote control
Spectrometry, Fluorescence
Tissue Distribution
Xenograft Model Antitumor Assays
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Summary:Developing a spatiotemporal-controlled platform with feasible synthesis and multifunctionality is highly desirable in the field of nanomedicine. Here, we present a near-infrared (NIR)-light-triggered approach to control the supramolecular assembly system for drug release and achieve synergistic chemo-photothermal therapy for cancer. A cucurbit[7]­uril (CB[7]) stabilized gold nanostar (GNS) platform is designed to encapsulate the anticancer drug camptothecin (CPT) via host–guest chemistry. Importantly, CB[7] behaves not only as a surfactant to improve the stability of GNS in the aqueous solution but also as the cage for intermolecular assembly of CPT molecules. Moreover, without the competitive complexation, the drug release could be stimulated under NIR light irradiation. Synergistic treatment of cancer can be achieved by combining chemotherapy with the photothermal effect of GNS. This work develops a NIR-light-triggered cucurbituril-based drug-release approach that opens the door for remote control of drug release in the supramolecular assembly system.
ISSN:1043-1802
1520-4812
DOI:10.1021/acs.bioconjchem.8b00438