Loading…
Pre-operative ADC predicts early recurrence of HCC after curative resection
Objectives To assess a correlation between the preoperative diffusion-weighted imaging (DWI) and early recurrence (
Saved in:
| Published in: | European radiology 2019-02, Vol.29 (2), p.1003-1012 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c438t-481058c83a48af484b33ee156dadae422532bc2b87d800958a8c4488851c824e3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c438t-481058c83a48af484b33ee156dadae422532bc2b87d800958a8c4488851c824e3 |
| container_end_page | 1012 |
| container_issue | 2 |
| container_start_page | 1003 |
| container_title | European radiology |
| container_volume | 29 |
| creator | Lee, Sunyoung Kim, Seong Hyun Hwang, Jeong Ah Lee, Ji Eun Ha, Sang Yun |
| description | Objectives
To assess a correlation between the preoperative diffusion-weighted imaging (DWI) and early recurrence ( |
| doi_str_mv | 10.1007/s00330-018-5642-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2073323786</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2071961540</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-481058c83a48af484b33ee156dadae422532bc2b87d800958a8c4488851c824e3</originalsourceid><addsrcrecordid>eNp1kMtKxDAUhoMoOl4ewI0U3LiJntymp0uplxEFXeg6ZNJT6TDTjkkr-PZmqBcQXAVOvv8_h4-xYwHnAiC_iABKAQeB3Ey15GaLTYRWkgtAvc0mUCjkeVHoPbYf4wIACqHzXbanAGSuASfs_ikQ79YUXN-8U3Z5VWbrQFXj-5iRC8uPLJAfQqDWU9bV2awsM1f3FLI0HTOBIvm-6dpDtlO7ZaSjr_eAvdxcP5cz_vB4e1dePnCvFfZcowCDHpXT6GqNeq4UkTDTylWOtJRGybmXc8wrTBcbdOi1RkQjPEpN6oCdjb3r0L0NFHu7aqKn5dK11A3RSsiVkirHaUJP_6CLbghtum5DiWIqjIZEiZHyoYsxUG3XoVm58GEF2I1pO5q2ybTdmLYmZU6-mof5iqqfxLfaBMgRiOmrfaXwu_r_1k_SHYZR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2071961540</pqid></control><display><type>article</type><title>Pre-operative ADC predicts early recurrence of HCC after curative resection</title><source>Springer Link</source><creator>Lee, Sunyoung ; Kim, Seong Hyun ; Hwang, Jeong Ah ; Lee, Ji Eun ; Ha, Sang Yun</creator><creatorcontrib>Lee, Sunyoung ; Kim, Seong Hyun ; Hwang, Jeong Ah ; Lee, Ji Eun ; Ha, Sang Yun</creatorcontrib><description>Objectives
To assess a correlation between the preoperative diffusion-weighted imaging (DWI) and early recurrence (<2 years) and to determine the best DWI parameters as the risk factor of early recurrence after surgery in single hepatocellular carcinoma (HCC).
Methods
The study included 114 patients with surgically resected single HCC (≤5 cm) who underwent preoperative magnetic resonance imaging (MRI) with DWI. Radiologists evaluated the diffusion restriction of the tumours using qualitative assessment and the mean and minimum apparent diffusion coefficient values (ADCmean and ADCmin) of the tumours using quantitative measurement. Clinical and laboratory findings and DWI parameters as a risk factor for early recurrence were identified by using Cox proportional hazards model.
Results
No significant difference was observed in early recurrence rates of HCCs between those with and those without diffusion restriction (
p
= 0.484). Early recurrence rates of HCCs with ADCmean and ADCmin values lower than the optimal cut-offs (1.023 and 0.773 × 10
-3
mm
2
/s, respectively) were significantly higher compared with those with values higher than the optimal cut-offs (
p
= 0.001 and
p
< 0.001, respectively). In the multivariable analysis, tumour size [hazard ratio (HR) per centimetre, 2.011; 95% CI, 1.304-3.102;
p
= 0.002] and ADCmin ≤0.773 × 10
-3
mm
2
/s (HR, 13.339; 95% CI, 4.422-40.240;
p
< 0.001) were independent risk factors for early HCC recurrence.
Conclusions
DWI is a promising imaging tool for early recurrence of HCC. Among qualitative and quantitative assessments of DWI, ADCmin is a significant risk factor for early recurrence after surgery in single HCC.
Key Points
• The performance of minimum apparent diffusion coefficient (ADCmin) is significantly better than that of mean apparent diffusion coefficient (ADCmean) for identifying early recurrence.
• ADCmin is a significantly independent risk factor of early HCC recurrence after surgery.
• ADCmin correlates with early recurrence after curative resection of single HCC, reflecting histopathological features of the tumours including histological grade and microvascular invasion.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-018-5642-5</identifier><identifier>PMID: 30027408</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Carcinoma, Hepatocellular - diagnostic imaging ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Chronic Disease ; Diagnostic Radiology ; Diffusion coefficient ; Diffusion Magnetic Resonance Imaging - methods ; Diffusion rate ; Female ; Gastrointestinal ; Hazard identification ; Hepatectomy ; Hepatocellular carcinoma ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Kaplan-Meier Estimate ; Liver cancer ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Magnetic resonance imaging ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Microvasculature ; Middle Aged ; Neoplasm Recurrence, Local - diagnostic imaging ; Neuroradiology ; NMR ; Nuclear magnetic resonance ; Observer Variation ; Parameter identification ; Preoperative Care - methods ; Prognosis ; Radiology ; Retrospective Studies ; Risk analysis ; Risk assessment ; Risk Factors ; Statistical models ; Surgery ; Time Factors ; Tumors ; Ultrasound</subject><ispartof>European radiology, 2019-02, Vol.29 (2), p.1003-1012</ispartof><rights>European Society of Radiology 2018</rights><rights>European Radiology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-481058c83a48af484b33ee156dadae422532bc2b87d800958a8c4488851c824e3</citedby><cites>FETCH-LOGICAL-c438t-481058c83a48af484b33ee156dadae422532bc2b87d800958a8c4488851c824e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30027408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Sunyoung</creatorcontrib><creatorcontrib>Kim, Seong Hyun</creatorcontrib><creatorcontrib>Hwang, Jeong Ah</creatorcontrib><creatorcontrib>Lee, Ji Eun</creatorcontrib><creatorcontrib>Ha, Sang Yun</creatorcontrib><title>Pre-operative ADC predicts early recurrence of HCC after curative resection</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To assess a correlation between the preoperative diffusion-weighted imaging (DWI) and early recurrence (<2 years) and to determine the best DWI parameters as the risk factor of early recurrence after surgery in single hepatocellular carcinoma (HCC).
Methods
The study included 114 patients with surgically resected single HCC (≤5 cm) who underwent preoperative magnetic resonance imaging (MRI) with DWI. Radiologists evaluated the diffusion restriction of the tumours using qualitative assessment and the mean and minimum apparent diffusion coefficient values (ADCmean and ADCmin) of the tumours using quantitative measurement. Clinical and laboratory findings and DWI parameters as a risk factor for early recurrence were identified by using Cox proportional hazards model.
Results
No significant difference was observed in early recurrence rates of HCCs between those with and those without diffusion restriction (
p
= 0.484). Early recurrence rates of HCCs with ADCmean and ADCmin values lower than the optimal cut-offs (1.023 and 0.773 × 10
-3
mm
2
/s, respectively) were significantly higher compared with those with values higher than the optimal cut-offs (
p
= 0.001 and
p
< 0.001, respectively). In the multivariable analysis, tumour size [hazard ratio (HR) per centimetre, 2.011; 95% CI, 1.304-3.102;
p
= 0.002] and ADCmin ≤0.773 × 10
-3
mm
2
/s (HR, 13.339; 95% CI, 4.422-40.240;
p
< 0.001) were independent risk factors for early HCC recurrence.
Conclusions
DWI is a promising imaging tool for early recurrence of HCC. Among qualitative and quantitative assessments of DWI, ADCmin is a significant risk factor for early recurrence after surgery in single HCC.
Key Points
• The performance of minimum apparent diffusion coefficient (ADCmin) is significantly better than that of mean apparent diffusion coefficient (ADCmean) for identifying early recurrence.
• ADCmin is a significantly independent risk factor of early HCC recurrence after surgery.
• ADCmin correlates with early recurrence after curative resection of single HCC, reflecting histopathological features of the tumours including histological grade and microvascular invasion.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Chronic Disease</subject><subject>Diagnostic Radiology</subject><subject>Diffusion coefficient</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Diffusion rate</subject><subject>Female</subject><subject>Gastrointestinal</subject><subject>Hazard identification</subject><subject>Hepatectomy</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Kaplan-Meier Estimate</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microvasculature</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - diagnostic imaging</subject><subject>Neuroradiology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Observer Variation</subject><subject>Parameter identification</subject><subject>Preoperative Care - methods</subject><subject>Prognosis</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk assessment</subject><subject>Risk Factors</subject><subject>Statistical models</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Tumors</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKxDAUhoMoOl4ewI0U3LiJntymp0uplxEFXeg6ZNJT6TDTjkkr-PZmqBcQXAVOvv8_h4-xYwHnAiC_iABKAQeB3Ey15GaLTYRWkgtAvc0mUCjkeVHoPbYf4wIACqHzXbanAGSuASfs_ikQ79YUXN-8U3Z5VWbrQFXj-5iRC8uPLJAfQqDWU9bV2awsM1f3FLI0HTOBIvm-6dpDtlO7ZaSjr_eAvdxcP5cz_vB4e1dePnCvFfZcowCDHpXT6GqNeq4UkTDTylWOtJRGybmXc8wrTBcbdOi1RkQjPEpN6oCdjb3r0L0NFHu7aqKn5dK11A3RSsiVkirHaUJP_6CLbghtum5DiWIqjIZEiZHyoYsxUG3XoVm58GEF2I1pO5q2ybTdmLYmZU6-mof5iqqfxLfaBMgRiOmrfaXwu_r_1k_SHYZR</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Lee, Sunyoung</creator><creator>Kim, Seong Hyun</creator><creator>Hwang, Jeong Ah</creator><creator>Lee, Ji Eun</creator><creator>Ha, Sang Yun</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190201</creationdate><title>Pre-operative ADC predicts early recurrence of HCC after curative resection</title><author>Lee, Sunyoung ; Kim, Seong Hyun ; Hwang, Jeong Ah ; Lee, Ji Eun ; Ha, Sang Yun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-481058c83a48af484b33ee156dadae422532bc2b87d800958a8c4488851c824e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Chronic Disease</topic><topic>Diagnostic Radiology</topic><topic>Diffusion coefficient</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Diffusion rate</topic><topic>Female</topic><topic>Gastrointestinal</topic><topic>Hazard identification</topic><topic>Hepatectomy</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Kaplan-Meier Estimate</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microvasculature</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - diagnostic imaging</topic><topic>Neuroradiology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Observer Variation</topic><topic>Parameter identification</topic><topic>Preoperative Care - methods</topic><topic>Prognosis</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk assessment</topic><topic>Risk Factors</topic><topic>Statistical models</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Tumors</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sunyoung</creatorcontrib><creatorcontrib>Kim, Seong Hyun</creatorcontrib><creatorcontrib>Hwang, Jeong Ah</creatorcontrib><creatorcontrib>Lee, Ji Eun</creatorcontrib><creatorcontrib>Ha, Sang Yun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Sunyoung</au><au>Kim, Seong Hyun</au><au>Hwang, Jeong Ah</au><au>Lee, Ji Eun</au><au>Ha, Sang Yun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pre-operative ADC predicts early recurrence of HCC after curative resection</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>29</volume><issue>2</issue><spage>1003</spage><epage>1012</epage><pages>1003-1012</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
To assess a correlation between the preoperative diffusion-weighted imaging (DWI) and early recurrence (<2 years) and to determine the best DWI parameters as the risk factor of early recurrence after surgery in single hepatocellular carcinoma (HCC).
Methods
The study included 114 patients with surgically resected single HCC (≤5 cm) who underwent preoperative magnetic resonance imaging (MRI) with DWI. Radiologists evaluated the diffusion restriction of the tumours using qualitative assessment and the mean and minimum apparent diffusion coefficient values (ADCmean and ADCmin) of the tumours using quantitative measurement. Clinical and laboratory findings and DWI parameters as a risk factor for early recurrence were identified by using Cox proportional hazards model.
Results
No significant difference was observed in early recurrence rates of HCCs between those with and those without diffusion restriction (
p
= 0.484). Early recurrence rates of HCCs with ADCmean and ADCmin values lower than the optimal cut-offs (1.023 and 0.773 × 10
-3
mm
2
/s, respectively) were significantly higher compared with those with values higher than the optimal cut-offs (
p
= 0.001 and
p
< 0.001, respectively). In the multivariable analysis, tumour size [hazard ratio (HR) per centimetre, 2.011; 95% CI, 1.304-3.102;
p
= 0.002] and ADCmin ≤0.773 × 10
-3
mm
2
/s (HR, 13.339; 95% CI, 4.422-40.240;
p
< 0.001) were independent risk factors for early HCC recurrence.
Conclusions
DWI is a promising imaging tool for early recurrence of HCC. Among qualitative and quantitative assessments of DWI, ADCmin is a significant risk factor for early recurrence after surgery in single HCC.
Key Points
• The performance of minimum apparent diffusion coefficient (ADCmin) is significantly better than that of mean apparent diffusion coefficient (ADCmean) for identifying early recurrence.
• ADCmin is a significantly independent risk factor of early HCC recurrence after surgery.
• ADCmin correlates with early recurrence after curative resection of single HCC, reflecting histopathological features of the tumours including histological grade and microvascular invasion.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30027408</pmid><doi>10.1007/s00330-018-5642-5</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2019-02, Vol.29 (2), p.1003-1012 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2073323786 |
| source | Springer Link |
| subjects | Adult Aged Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Chronic Disease Diagnostic Radiology Diffusion coefficient Diffusion Magnetic Resonance Imaging - methods Diffusion rate Female Gastrointestinal Hazard identification Hepatectomy Hepatocellular carcinoma Humans Imaging Internal Medicine Interventional Radiology Kaplan-Meier Estimate Liver cancer Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Liver Neoplasms - surgery Magnetic resonance imaging Male Medical imaging Medicine Medicine & Public Health Microvasculature Middle Aged Neoplasm Recurrence, Local - diagnostic imaging Neuroradiology NMR Nuclear magnetic resonance Observer Variation Parameter identification Preoperative Care - methods Prognosis Radiology Retrospective Studies Risk analysis Risk assessment Risk Factors Statistical models Surgery Time Factors Tumors Ultrasound |
| title | Pre-operative ADC predicts early recurrence of HCC after curative resection |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T14%3A18%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pre-operative%20ADC%20predicts%20early%20recurrence%20of%20HCC%20after%20curative%20resection&rft.jtitle=European%20radiology&rft.au=Lee,%20Sunyoung&rft.date=2019-02-01&rft.volume=29&rft.issue=2&rft.spage=1003&rft.epage=1012&rft.pages=1003-1012&rft.issn=0938-7994&rft.eissn=1432-1084&rft_id=info:doi/10.1007/s00330-018-5642-5&rft_dat=%3Cproquest_cross%3E2071961540%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c438t-481058c83a48af484b33ee156dadae422532bc2b87d800958a8c4488851c824e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2071961540&rft_id=info:pmid/30027408&rfr_iscdi=true |