Glycemic variability in the development of cardiovascular complications in diabetes

Summary Diabetes mellitus represents a major risk factor for the development of coronary artery disease and other vascular complications. Glycated haemoglobin, fructosamine, and fasting blood glucose levels are partial parameters to exhaustively describe patient dysglycemic status. Thus, recently th...

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Bibliographic Details
Published in:Diabetes/metabolism research and reviews 2018-11, Vol.34 (8), p.e3047-n/a
Main Authors: Nusca, Annunziata, Tuccinardi, Dario, Albano, Marzia, Cavallaro, Camilla, Ricottini, Elisabetta, Manfrini, Silvia, Pozzilli, Paolo, Di Sciascio, Germano
Format: Article
Language:English
Subjects:
Blood Glucose - metabolism
cardiovascular complications
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - etiology
Coronary artery
coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - etiology
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetic Angiopathies - blood
Diabetic Angiopathies - etiology
Glucose
Glycated Hemoglobin A - metabolism
glycemic variability
Heart diseases
Hemoglobin
Humans
Hyperglycemia
Patients
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Summary:Summary Diabetes mellitus represents a major risk factor for the development of coronary artery disease and other vascular complications. Glycated haemoglobin, fructosamine, and fasting blood glucose levels are partial parameters to exhaustively describe patient dysglycemic status. Thus, recently the new concept of glycemic variability has emerged, including information about two major aspects: the magnitude of blood glucose excursions (from nadir to peak, thus lower and higher spikes) and the time intervals in which these fluctuations occur. Despite the lack of consensus regarding the most appropriate definition and tools for its assessment, glycemic variability seems to have more deleterious effects than sustained hyperglycemia in the pathogenesis of diabetic cardiovascular complications. This manuscript aimed to review the most recent evidence on glycemic variability and its potential use in everyday clinical practice to identify diabetic patients at higher risk of cardiovascular complications and thus needing stricter monitoring and treatment.
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.3047