Could perfusion heterogeneity at dynamic contrast-enhanced MRI be used to predict rectal cancer sensitivity to chemoradiotherapy?

To evaluate whether perfusion heterogeneity of rectal cancer prior to chemoradiotherapy (CRT) using histogram analysis of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) quantitative parameters can predict response to treatment. Twenty-one patients with histologically proven rectal...

Full description

Saved in:
Bibliographic Details
Published in:Clinical radiology 2018-10, Vol.73 (10), p.911.e1-911.e7
Main Authors: Palmisano, A., Esposito, A., Rancoita, P.M.V., Di Chiara, A., Passoni, P., Slim, N., Campolongo, M., Albarello, L., Fiorino, C., Rosati, R., Del Maschio, A., De Cobelli, F.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Chemoradiotherapy
Contrast Media
Female
Humans
Magnetic Resonance Imaging - methods
Male
Middle Aged
Neoadjuvant Therapy
Prospective Studies
Rectal Neoplasms - pathology
Rectal Neoplasms - therapy
Retrospective Studies
ROC Curve
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate whether perfusion heterogeneity of rectal cancer prior to chemoradiotherapy (CRT) using histogram analysis of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) quantitative parameters can predict response to treatment. Twenty-one patients with histologically proven rectal adenocarcinoma were enrolled prospectively. All patients underwent 1.5 T DCE-MRI before CRT. Tumour volumes were drawn on Ktrans and Ve maps, using T2-weighted (W) images as reference, and the following first-order texture parameters of Ve and Ktrans values were extracted: 25th, 50th, 75th percentile, mean, standard deviation, skewness, and kurtosis. After CRT, patients underwent surgery and according with Rödel's tumour regression grade (TRG), they were classified as poor responders “non-GR” (TRG 0–2) and good responders “GR” (TRG 3–4). Differences between GR and non-GR in DCE-MRI first-order texture parameters were evaluated using the Mann–Whitney test, and their role in the prediction of response was investigated using receiver operating characteristic (ROC) curve analysis. Sixteen (76%) patients were classified as GR and five (24%) were non-GR. Skewness and kurtosis of Ve was significantly higher in non-GR (4.886±1.320 and 36.402±24.486, respectively) than in GR patients (1.809±1.280, p=0.003 and 6.268±8.130, p= 0.011). Ve skewness
ISSN:0009-9260
1365-229X
DOI:10.1016/j.crad.2018.06.007