Analysis of Endocrine Disruptors, Pharmaceuticals, and Personal Care Products in Water Using Liquid Chromatography/Tandem Mass Spectrometry

A method has been developed for the trace analysis of 27 compounds from a diverse group of pharmaceuticals, steroids, pesticides, and personal care products. The method employs solid-phase extraction (SPE) and liquid chromatography/tandem mass spectrometry (LC/MS/MS), using electrospray ionization (...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2003-11, Vol.75 (22), p.6265-6274
Main Authors: Vanderford, Brett J, Pearson, Rebecca A, Rexing, David J, Snyder, Shane A
Format: Article
Language:English
Subjects:
Analysis methods
Analytical chemistry
Applied sciences
Chemistry
Chromatographic methods and physical methods associated with chromatography
Chromatography
Chromatography, Liquid
Endocrine disruptors
Endocrine system
Exact sciences and technology
Formaldehyde
Hygiene
Liquids
Natural water pollution
Nevada
Other chromatographic methods
Personal care industry
Pesticides - analysis
Pharmaceutical Preparations - analysis
Pharmaceuticals
Pollution
Preservatives, Pharmaceutical
Reference Standards
Spectrometric and optical methods
Spectrometry, Mass, Electrospray Ionization
Spectrum analysis
Steroids - analysis
Sulfuric Acids
Water
Water - chemistry
Water Pollutants - analysis
Water treatment and pollution
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Summary:A method has been developed for the trace analysis of 27 compounds from a diverse group of pharmaceuticals, steroids, pesticides, and personal care products. The method employs solid-phase extraction (SPE) and liquid chromatography/tandem mass spectrometry (LC/MS/MS), using electrospray ionization (ESI) in both positive and negative modes and atmospheric pressure chemical ionization in positive mode. Unlike many previous methods, a single SPE procedure using 1 L of water coupled to a simple LC method is used for all ionization modes. Instrument detection limits for most compounds were below 1.0 pg on column with reporting limits of 1.0 ng/L in water. Recoveries for most compounds in deionized water were greater than 80%. Sulfuric acid was found to be the preferred sample preservative, and structures of all MS/MS product ions are proposed. Matrix effects from waters with a high content of treated municipal effluent were observed in both ESI modes and are discussed in the paper.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac034210g