Genetic Proof-of-Concept for Cardiac Gene Expression in Human Circulating Blood-Derived Progenitor Cells

To the Editor: Transplantation of adult bone marrow- or blood-derived autologous progenitor cells is a promising option for treatment of patients with acute myocardial infarction or heart failure. Studying a patient with a well-defined mutation in the cardiac troponin T (TnT) gene offered the unique...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American College of Cardiology 2008-06, Vol.51 (23), p.2289-2290
Main Authors: Rupp, Stefan, MD, Koyanagi, Masamichi, MD, Iwasaki, Masayoshi, MD, Diehl, Florian, PhD, Bushoven, Philipp, Schranz, Dietmar, MD, Zeiher, Andreas M., MD, Dimmeler, Stefanie, PhD
Format: Article
Language:English
Subjects:
Animals
Blood
Cardiology
Cardiomyocytes
Cardiomyopathy, Dilated - genetics
Cardiomyopathy, Dilated - therapy
Cardiovascular
Cloning
Deoxyribonucleic acid
DNA
Gene Expression
Heart
Heart Failure - therapy
Internal Medicine
Mutation
Myocardial Infarction - genetics
Myocardial Infarction - therapy
Myocardium - cytology
Rats
Stem Cell Transplantation
Stem Cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To the Editor: Transplantation of adult bone marrow- or blood-derived autologous progenitor cells is a promising option for treatment of patients with acute myocardial infarction or heart failure. Studying a patient with a well-defined mutation in the cardiac troponin T (TnT) gene offered the unique opportunity to provide genetic proof for cardiac marker gene expression in patient-derived circulating cells after the induction of cardiac differentiation in vitro.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2008.01.062