3D printed porous β-Ca2SiO4 scaffolds derived from preceramic resin and their physicochemical and biological properties

• Published in: Science and technology of advanced materials 2018-12, Vol.19 (1), p.495-506
• Main Authors: Fu, Shengyang, Liu, Wei, Liu, Shiwei, Zhao, Shichang, Zhu, Yufang
• Format: Article
• Language: English
• Subjects: 107 Glass and ceramic materials; 211 Scaffold / Tissue engineering / Drug delivery; 30 Bio-inspired and biomedical materials; 3D printing; Alkaline phosphatase; Apatite; Bio-Inspired and Biomedical Materials; Bioceramics; Biological properties; Biomedical materials; bone tissue engineering; Bones; Calcium carbonate; Compressive strength; Dicalcium silicate; Fillers; Gene expression; Porosity; preceramic resin; Resins; Scaffolds; Sintering (powder metallurgy); SiO; Stem cells; Three dimensional printing; Tissue engineering; β-Ca; β-Ca2SiO4
• ISSN: 1468-6996; 1878-5514
• DOI: 10.1080/14686996.2018.1471653

Silicate bioceramic scaffolds are of great interest in bone tissue engineering, but the fabrication of silicate bioceramic scaffolds with complex geometries is still challenging. In this study, three-dimensional (3D) porous β-Ca 2 SiO 4 scaffolds have been successfully fabricated from preceramic resin loaded with CaCO 3 active filler by 3D printing. The fabricated β-Ca 2 SiO 4 scaffolds had uniform interconnected macropores (ca. 400 μm), high porosity (>78%), enhanced mechanical strength (ca. 5.2 MPa), and excellent apatite mineralization ability. Importantly, the results showed that the increase of sintering temperature significantly enhanced the compressive strength and the scaffolds sintered at higher sintering temperature stimulated the adhesion, proliferation, alkaline phosphatase activity, and osteogenic-related gene expression of rat bone mesenchymal stem cells. Therefore, the 3D printed β-Ca 2 SiO 4 scaffolds derived from preceramic resin and CaCO 3 active fillers would be promising candidates for bone tissue engineering.