Gluing Pills Technology: A novel route to multilayer tablet manufacturing

[Display omitted] Layer weight control, delamination and cross-contamination are major challenges in the production of compacted multilayer tablets (MLT). In this work, we describe a novel approach to manufacturing MLT: the Gluing Pills Technology (GPT). High loads of ibuprofen free acid and caffein...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 2018-09, Vol.548 (1), p.672-681
Main Authors: Demiri, Valjon, Stranzinger, Sandra, Rinner, Paul, Piller, Michael, Sacher, Stephan, Lingitz, Josef, Khinast, Johannes, Salar-Behzadi, Sharareh
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Caffeine - chemistry
Cross-contamination
Delamination
Drug Combinations
Elasticity
Excipients - chemistry
Flexible-dose combination
Gelatin - chemistry
Gluing Pills Technology
Ibuprofen - chemistry
Multilayer tablets
Personalized medicine
Porosity
Povidone - chemistry
Tablets - chemistry
Technology, Pharmaceutical - methods
Tensile Strength
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] Layer weight control, delamination and cross-contamination are major challenges in the production of compacted multilayer tablets (MLT). In this work, we describe a novel approach to manufacturing MLT: the Gluing Pills Technology (GPT). High loads of ibuprofen free acid and caffeine anhydrate were blended with microcrystalline cellulose (MCC) and dibasic calcium phosphate dihydrate (DCPD) and compacted into monolayer tablets. They were glued together via the GPT using solutions of either fish gelatin or polyvinylpyrrolidone K90 as gluing agents with defined viscosity. Factors that have a substantial impact on the deformation behavior of blends (i.e., elastic recovery, tensile strength and porosity) of monolayer tablets were investigated in terms of bilayer tablets manufactured via the GPT. The results indicated that high levels of elastic recovery negatively affected the robustness of GPT bilayer tablets and that the type of gluing agent was critical. Raman microscopy analysis was successfully applied to qualitatively assess the function of gluing layer as a barrier to cross-contamination between two monolayer tablets. This study shows the feasibility of the GPT for manufacturing of robust MLT, emphasizing its potential in terms of real-time production of individualized fixed-dose combinations and application in both translational pharmaceutics and personalized medicine.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2018.07.004