Impact of primary tumour location and RAS/BRAF mutational status in metastatic colorectal cancer treated with first-line regimens containing oxaliplatin and bevacizumab: Prognostic factors from the AIO KRK0207 first-line and maintenance therapy trial

The major prognostic relevance of primary tumour location (LPT) in advanced colorectal cancer was shown in large retrospective studies, but quantitative estimates are highly heterogeneous, and there is still limited information about its impact within the framework of biomarker-guided treatment stra...

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Bibliographic Details
Published in:European journal of cancer (1990) 2018-09, Vol.101, p.105-113
Main Authors: Hegewisch-Becker, Susanna, Nöpel-Dünnebacke, Stefanie, Hinke, Axel, Graeven, Ullrich, Reinacher-Schick, Anke, Hertel, Jan, Lerchenmüller, Christian A., Killing, Birgitta, Depenbusch, Reinhard, Al-Batran, Salah-Eddin, Lange, Thoralf, Dietrich, Georg, Tannapfel, Andrea, Arnold, Dirk
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Bevacizumab
Bevacizumab - administration & dosage
Biomarkers
BRAF mutation
Cancer
Cancer therapies
Carcinoembryonic antigen
Colon - drug effects
Colon - metabolism
Colon - pathology
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - genetics
Confidence intervals
Endoscopy
Female
First-line therapy
Humans
Immunotherapy
Kaplan-Meier Estimate
Maintenance Chemotherapy
Male
Medical treatment
Metastases
Middle Aged
Monoclonal antibodies
Mutation
Overall survival
Oxaliplatin
Oxaliplatin - administration & dosage
Patients
Platelets
Primary tumour location
Prognosis
Prognostic factors
Proto-Oncogene Proteins B-raf - genetics
Rank tests
RAS mutation
ras Proteins - genetics
Rectum - drug effects
Rectum - metabolism
Rectum - pathology
Retrospective Studies
Subgroups
Surgery
Survival
Targeted cancer therapy
Tumors
Young Adult
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Summary:The major prognostic relevance of primary tumour location (LPT) in advanced colorectal cancer was shown in large retrospective studies, but quantitative estimates are highly heterogeneous, and there is still limited information about its impact within the framework of biomarker-guided treatment strategies. Therefore, we analysed LPT in relation to other clinical and molecular parameters, based on mature survival data from the recent randomised AIO KRK0207 trial. Patients uniformly received first-line induction treatment with a combination of bevacizumab, oxaliplatin and fluoropyrimidine. LPT was retrospectively determined using surgical reports, pathology reports and endoscopy reports. The prognostic analyses were performed using Kaplan–Meier estimations and log-rank tests, while hazard ratios (HRs) and multivariable results were derived from Cox models. Among 754 patients with unequivocal information on LPT, patients with left-sided tumours showed a median overall survival of 24.8 months compared with the right-sided cohort with 18.4 months (HR: 1.54, 95% confidence interval: 1.30–1.81, P 
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2018.06.015