Genetic susceptibility of glutathione S‐transferase genes (GSTM1/T1 and P1) to coronary artery disease in Asian Indians

Genetic polymorphisms in glutathione S‐transferase (GST) genes may modulate the risk of cardiovascular diseases. The objective of present study was to investigate the potential association between the polymorphisms of GSTM1/T1 and P1 genes and their influence on diverse clinical parameters and oxida...

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Bibliographic Details
Published in:Annals of human genetics 2018-11, Vol.82 (6), p.448-456
Main Authors: Bhatti, J. S., Vijayvergiya, R., Singh, B., Bhatti, G. K.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antioxidants
Asian Continental Ancestry Group
Biomarkers
Body fat
Body mass index
Cardiovascular disease
Cardiovascular diseases
Case-Control Studies
Cholesterol
Coronary artery
coronary artery disease
Coronary Artery Disease - genetics
Coronary vessels
Data processing
Female
Genetic diversity
Genetic Predisposition to Disease
gene polymorphism
Genotype
Genotype & phenotype
Genotyping
Glutathione S-Transferase pi - genetics
Glutathione transferase
Glutathione Transferase - genetics
GSTM1 protein
GSTs
GSTT1 protein
Heart diseases
Hip
Humans
India
Indian population
Lipid Peroxidation
Male
Malondialdehyde
Middle Aged
Oxidative Stress
Polymorphism, Genetic
Triglycerides
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Summary:Genetic polymorphisms in glutathione S‐transferase (GST) genes may modulate the risk of cardiovascular diseases. The objective of present study was to investigate the potential association between the polymorphisms of GSTM1/T1 and P1 genes and their influence on diverse clinical parameters and oxidative stress biomarkers in coronary artery disease (CAD) patients in Asian Indians. The present study includes 562 angiographically confirmed CAD patients and 564 healthy control subjects from the north Indian population. Anthropometric and clinical measurements were performed for all the participants. The oxidative stress biomarkers including malondialdehyde and total antioxidant capacity were also measured. The genotyping of the GSTM1/T1 and P1 genes was performed using the multiplex‐PCR and PCR‐RFLP methods. The CAD patients exhibit significantly high values of waist circumference, waist‐to‐hip ratio, body fat (%), glucose, triglycerides, and very low‐density lipoprotein, and reduced high‐density lipoprotein levels compared to control subjects (P 
ISSN:0003-4800
1469-1809
DOI:10.1111/ahg.12274