Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models

Host lipid metabolism is an important target for subversion by pathogenic mycobacteria such as Mycobacterium tuberculosis. The appearance of foam cells within the granuloma are well-characterised effects of chronic tuberculosis. The zebrafish-Mycobacterium marinum infection model recapitulates many...

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Bibliographic Details
Published in:Developmental and comparative immunology 2018-11, Vol.88, p.169-172
Main Authors: Johansen, Matt D., Kasparian, Joshua A., Hortle, Elinor, Britton, Warwick J., Purdie, Auriol C., Oehlers, Stefan H.
Format: Article
Language:English
Subjects:
Animals
Antigens, Bacterial - immunology
Bacterial Proteins - immunology
Cell Transdifferentiation - immunology
Disease Models, Animal
Foam cell
Foam Cells - physiology
Granuloma
Granuloma - immunology
Granuloma - microbiology
Humans
Lipid
Lipid Metabolism - immunology
Macrophages - physiology
Mycobacterium
Mycobacterium Infections, Nontuberculous - immunology
Mycobacterium Infections, Nontuberculous - microbiology
Mycobacterium marinum - immunology
Mycobacterium marinum - pathogenicity
Mycobacterium tuberculosis - immunology
Mycobacterium tuberculosis - pathogenicity
Pathogenesis
Tuberculosis - immunology
Tuberculosis - microbiology
Zebrafish
Zebrafish - physiology
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Summary:Host lipid metabolism is an important target for subversion by pathogenic mycobacteria such as Mycobacterium tuberculosis. The appearance of foam cells within the granuloma are well-characterised effects of chronic tuberculosis. The zebrafish-Mycobacterium marinum infection model recapitulates many aspects of human-M. tuberculosis infection and is used as a model to investigate the structural components of the mycobacterial granuloma. Here, we demonstrate that the zebrafish-M. marinum granuloma contains foam cells and that the transdifferentiation of macrophages into foam cells is driven by the mycobacterial ESX1 pathogenicity locus. This report demonstrates conservation of an important aspect of mycobacterial infection across species. •Foam cells are identified by Oil Red O staining in zebrafish adults and embryos infected with Mycobacterium marinum.•The transdifferentiation of macrophages into foam cells is driven by the mycobacterial pathogenicity locus ESX1.•Zebrafish are an emerging model for studying mycobacterial infection-induced abnormalities in lipid metabolism.
ISSN:0145-305X
1879-0089
DOI:10.1016/j.dci.2018.07.022