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Light-up RNA aptamer enabled label-free protein detection via a proximity induced transcription assay
A novel proximity induced transcription assay for highly sensitive protein detection based on protein mediated ligation of a DNA template with the transcription of a light-up RNA aptamer for signal amplification has been developed.
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| Published in: | Chemical communications (Cambridge, England) England), 2018, Vol.54 (64), p.8877-8880 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c315t-91e47b8ca27a59e16aede7c6d4436d44e9734bd891994a95a3ca7b313ffdfcca3 |
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| cites | cdi_FETCH-LOGICAL-c315t-91e47b8ca27a59e16aede7c6d4436d44e9734bd891994a95a3ca7b313ffdfcca3 |
| container_end_page | 8880 |
| container_issue | 64 |
| container_start_page | 8877 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 54 |
| creator | Ying, Zhan-Ming Xiao, Hu-Yan Tang, Hao Yu, Ru-Qin Jiang, Jian-Hui |
| description | A novel proximity induced transcription assay for highly sensitive protein detection based on protein mediated ligation of a DNA template with the transcription of a light-up RNA aptamer for signal amplification has been developed. |
| doi_str_mv | 10.1039/c8cc04498h |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2018, Vol.54 (64), p.8877-8880 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2076237118 |
| source | Royal Society of Chemistry |
| subjects | Antibodies - immunology Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - genetics Base Sequence Biosensing Techniques - methods Deoxyribonucleic acid DNA DNA - genetics DNA - metabolism DNA Ligases - metabolism DNA Probes - genetics DNA Probes - metabolism DNA-Directed RNA Polymerases - metabolism Fluorescent Dyes - chemistry Fluoroimmunoassay - methods Humans Limit of Detection Male Nucleic Acid Amplification Techniques - methods Nucleic Acid Hybridization Prostate-Specific Antigen - blood Prostate-Specific Antigen - immunology Proteins Ribonucleic acid RNA Transcription, Genetic Viral Proteins - metabolism |
| title | Light-up RNA aptamer enabled label-free protein detection via a proximity induced transcription assay |
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