The effect of vitamin D3 supplementation on markers of cardiovascular health in hyperparathyroid, vitamin D insufficient women: a randomized placebo-controlled trial

Purpose Emerging data supports an association between parathyroid hormone (PTH) and aldosterone. It has been speculated, that potential adverse cardiovascular effects of vitamin D insufficiency may partly be caused by the development of secondary hyperparathyroidism with increased activity of the re...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine 2018-10, Vol.62 (1), p.182-194
Main Authors: Bislev, Lise Sofie, Langagergaard Rødbro, Lene, Bech, Jesper Nørgaard, Pedersen, Erling Bjerregaard, Kjaergaard, Alisa D., Ladefoged, Søren Andreas, Rolighed, Lars, Sikjaer, Tanja, Rejnmark, Lars
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Aged
Aged, 80 and over
Aldosterone
Angiotensin
Blood pressure
Blood Pressure - drug effects
Blood Pressure - physiology
Cardiovascular System - drug effects
Cardiovascular System - physiopathology
Cholecalciferol - administration & dosage
Cholecalciferol - therapeutic use
Diabetes
Double-Blind Method
Endocrinology
Female
Heart rate
Heart Rate - drug effects
Heart Rate - physiology
Hemoglobin
High density lipoprotein
Hormone Replacement Therapy
Humanities and Social Sciences
Humans
Hyperparathyroidism
Hyperparathyroidism - complications
Hyperparathyroidism - physiopathology
Internal Medicine
Lipids
Lipoproteins
Medicine
Medicine & Public Health
Middle Aged
multidisciplinary
Original Article
Parathyroid
Parathyroid hormone
Plasma levels
Post-menopause
Renin
Science
Supplements
Treatment Outcome
Vascular Stiffness - drug effects
Vascular Stiffness - physiology
Vitamin D
Vitamin D Deficiency - complications
Vitamin D Deficiency - drug therapy
Vitamin D Deficiency - physiopathology
Vitamin D3
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Emerging data supports an association between parathyroid hormone (PTH) and aldosterone. It has been speculated, that potential adverse cardiovascular effects of vitamin D insufficiency may partly be caused by the development of secondary hyperparathyroidism with increased activity of the renin-angiotensin-aldosterone system (RAAS). We aimed to investigate the effect of normalizing vitamin D status and/or reducing PTH levels on RAAS activity and other markers of cardiovascular health. Methods In a double-blinded study during wintertime, we randomized 81 healthy postmenopausal women with secondary hyperparathyroidism (PTH > 6.9 pmol/l) and 25-hydroxy-vitamin D (25(OH)D) levels 
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-018-1659-4