Effect of retinoic acid on hemolymph glucose regulation in the fresh water edible crab Oziotelphusa senex senex

Abstract 9- cis -Retinoic acid (9CRA) and all- trans -retinoic acid (ATRA) are known to be involved in the regulation of glucose homeostasis in vertebrates by inducing insulin release and expression of glucose reporter proteins. In view of the fact that 9CRA and ATRA are endogenous in crustaceans an...

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Bibliographic Details
Published in:General and comparative endocrinology 2008-02, Vol.155 (3), p.496-502
Main Authors: Reddy, P. Sreenivasula, Sainath, S.B
Format: Article
Language:English
Subjects:
Animals
Arthropod Proteins
Blood Glucose - metabolism
Brachyura - drug effects
Brachyura - metabolism
Endocrine Glands - chemistry
Endocrine Glands - metabolism
Endocrinology & Metabolism
Eye - chemistry
Eye - metabolism
Eyestalks
Fresh Water
Hemolymph - chemistry
Hemolymph - metabolism
Hemolymph glucose
Hyperglycemia - chemically induced
Hyperglycemic hormone
Invertebrate Hormones
Male
Marine
Nerve Tissue Proteins - chemistry
Nerve Tissue Proteins - pharmacology
Oziotelphusa
Oziotelphusa senex senex
Retinoic acid
Tissue Extracts - pharmacology
Tretinoin - pharmacology
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Summary:Abstract 9- cis -Retinoic acid (9CRA) and all- trans -retinoic acid (ATRA) are known to be involved in the regulation of glucose homeostasis in vertebrates by inducing insulin release and expression of glucose reporter proteins. In view of the fact that 9CRA and ATRA are endogenous in crustaceans and a retinoic acid X-receptor exists in crabs, we investigated whether 9CRA and ATRA also plays a role in glucose homeostasis in freshwater crab, Oziotelphusa senex senex . Injection of 9CRA into intact crabs significantly increased the hemolymph glucose level in a dose-dependent manner. Such 9CRA-induced hyperglycemia was apparently mediated by the CHH since injection of 9CRA into eyestalk-ablated crabs did not result in hyperglycemia. In support of this, administration of 9CRA in to crabs resulted in reduced hyperglycemic activity of eyestalks and elevated titers of CHH in hemolymph. ATRA injection did not cause any changes in hemolymph glucose and CHH levels. The results provide the first evidence that 9- cis -retinoic acid, but not all- trans -retinoic acid, is involved in the regulation of glucose homeostasis and apparently mediated by the eyestalk hormone CHH.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2007.09.013