In-Cell Titration of Small Solutes Controls Protein Stability and Aggregation

The components of the intracellular environment vary widely in size: from large multiprotein complexes to atomic ions. Besides water, low-molecular-weight solutes (

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Bibliographic Details
Published in:Journal of the American Chemical Society 2018-08, Vol.140 (33), p.10497-10503
Main Authors: Sukenik, Shahar, Salam, Mohammed, Wang, Yuhan, Gruebele, Martin
Format: Article
Language:English
Subjects:
Carbohydrates - chemistry
Cell Line, Tumor
Fluorescence Resonance Energy Transfer
Humans
Protein Binding
Protein Stability
Salts - chemistry
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Description
Summary:The components of the intracellular environment vary widely in size: from large multiprotein complexes to atomic ions. Besides water, low-molecular-weight solutes (
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.8b04809