Morphea: Current concepts

Abstract Morphea is an inflammatory, sclerosing skin disorder that can involve the underlying soft tissues. Although the cause of morphea remains poorly investigated, genetic predisposition, immune dysregulation, and environmental factors have been implicated. Morphea is associated with cosmetic and...

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Bibliographic Details
Published in:Clinics in dermatology 2018-07, Vol.36 (4), p.475-486
Main Authors: Florez-Pollack, Stephanie, BS, Kunzler, Elaine, BS, Jacobe, Heidi T., MD, MSCS
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Dermatology
Diagnosis, Differential
Humans
Immunosuppressive Agents - therapeutic use
Magnetic Resonance Imaging
Methotrexate - therapeutic use
Scleroderma, Localized - complications
Scleroderma, Localized - diagnosis
Scleroderma, Localized - diagnostic imaging
Scleroderma, Localized - therapy
Ultrasonography
Ultraviolet Therapy
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Summary:Abstract Morphea is an inflammatory, sclerosing skin disorder that can involve the underlying soft tissues. Although the cause of morphea remains poorly investigated, genetic predisposition, immune dysregulation, and environmental factors have been implicated. Morphea is associated with cosmetic and functional sequelae, and internal organ involvement is rare. Early diagnosis and treatment are imperative to minimize damage such as limitation of range of motion. This review summarizes advances in diagnosis and treatment of morphea, allowing clinicians to better serve patients with this condition.
ISSN:0738-081X
1879-1131
DOI:10.1016/j.clindermatol.2018.04.005