DNA repair and cyclin D1 polymorphisms and styrene-induced genotoxicity and immunotoxicity

1-SO-adenine DNA adducts, DNA single-strand breaks (SBs), chromosomal aberrations (CAs), mutant frequency (MF) at the HPRT gene, and immune parameters (hematological and of humoral immunity) were studied in styrene-exposed human subjects and controls. Results were correlated with genetic polymorphis...

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Published in:Toxicology and applied pharmacology 2005-09, Vol.207 (2), p.302-309
Main Authors: Kuricova, M., Naccarati, A., Kumar, R., Koskinen, M., Sanyal, S., Dusinska, M., Tulinska, J., Vodickova, L., Liskova, A., Jahnova, E., Fuortes, L., Haufroid, V., Hemminki, K., Vodicka, P.
Format: Article
Language:English
Subjects:
Adult
Cyclin D1 - genetics
DNA Repair
Female
Humans
Immune System - drug effects
Immunotoxicity
Individual susceptibility
Male
Middle Aged
Mutagens - toxicity
Occupational Exposure
Polymorphism, Genetic
Styrene - toxicity
Styrene genotoxicity
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Summary:1-SO-adenine DNA adducts, DNA single-strand breaks (SBs), chromosomal aberrations (CAs), mutant frequency (MF) at the HPRT gene, and immune parameters (hematological and of humoral immunity) were studied in styrene-exposed human subjects and controls. Results were correlated with genetic polymorphisms in DNA repair genes ( XPD, exon 23, XPG, exon 15, XPC, exon 15, XRCC1, exon 10, XRCC3, exon 7) and cell cycle gene cyclin D1. Results for biomarkers of genotoxicity after stratification for the different DNA repair genetic polymorphisms showed that the polymorphism in exon 23 of the XPD gene modulates levels of chromosomal and DNA damage, HPRT MF, and moderately affects DNA adduct levels. The highest levels of biomarkers were associated with the wild-type homozygous AA genotype. The exposed individuals with the wild-type GG genotype for XRCC1 gene exhibited the lowest CA frequencies, compared to those with an A allele ( P 
ISSN:0041-008X
1096-0333
DOI:10.1016/j.taap.2004.12.023