Clock Gene Modulation by TNF-Ic Depends on Calcium and p38 MAP Kinase Signaling

A 24-h treatment with the cytokine tumor necrosis factor-Ic (TNF-Ic) suppresses transcription of E-box-driven clock genes (D-site albumin promoter binding protein, Dbp; Tyrotroph embryonic factor, Tef ; Hepatic leukemia factor, Hlf; Period homolog to Drosophila 1/2/3, Per1, Per2, and Per3) by yet un...

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Bibliographic Details
Published in:Journal of biological rhythms 2009-08, Vol.24 (4), p.283-294
Main Authors: Petrzilka, Saskia, Taraborrelli, Cornelia, Cavadini, Gionata, Fontana, Adriano, Birchler, Thomas
Format: Article
Language:English
Subjects:
Drosophila
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Summary:A 24-h treatment with the cytokine tumor necrosis factor-Ic (TNF-Ic) suppresses transcription of E-box-driven clock genes (D-site albumin promoter binding protein, Dbp; Tyrotroph embryonic factor, Tef ; Hepatic leukemia factor, Hlf; Period homolog to Drosophila 1/2/3, Per1, Per2, and Per3) by yet unknown molecular mechanisms. The attenuation of clock genes has been suggested as a putative cause for the development of sickness behavior syndrome in infectious and autoimmune diseases. Here, the authors studied the effect of TNF-Ic at early time points (
ISSN:0748-7304
1552-4531
DOI:10.1177/0748730409336579