Evaluation of genotoxic effects of sodium propionate, calcium propionate and potassium propionate on the root meristem cells of Allium cepa

The effects of different treatments with food preservatives, sodium propionate (SP), calcium propionate (CP) and potassium propionate (PP), on the cytology and DNA content of Allium cepa were investigated. Five concentrations of these additives – 1000, 1500, 2000, 2500, and 3000ppm – were applied fo...

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Bibliographic Details
Published in:Food and chemical toxicology 2008-06, Vol.46 (6), p.2035-2041
Main Author: TURKOGLU, Sifa
Format: Article
Language:English
Subjects:
Allium - drug effects
Allium - genetics
Allium cepa
Biological and medical sciences
Calcium
Calcium propionate
cell division
Cell Nucleus - chemistry
chromosome aberrations
Chromosome Aberrations - drug effects
Chromosomes, Plant - drug effects
Chromosomes, Plant - ultrastructure
cultured cells
Cytogenetics
DNA content
DNA, Plant - biosynthesis
DNA, Plant - genetics
dosage
food preservatives
Genotoxic effect
genotoxicity
Medical sciences
Meristem - chemistry
Meristem - cytology
Mitosis
Mitosis - drug effects
Mitotic Index
Mutagens
nuclear DNA content
onions
Potassium
Potassium propionate
propionates
Propionates - toxicity
root meristems
Sodium
Sodium propionate
Toxicology
vegetable crops
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Summary:The effects of different treatments with food preservatives, sodium propionate (SP), calcium propionate (CP) and potassium propionate (PP), on the cytology and DNA content of Allium cepa were investigated. Five concentrations of these additives – 1000, 1500, 2000, 2500, and 3000ppm – were applied for 24, 48, and 72h. All concentrations of these chemicals showed an inhibitory effect on cell division in root-tips of A. cepa and caused a decrease in mitotic index values. Additionally, all treatments changed the frequency of mitotic phases when compared with the control groups. These compounds increased chromosome abnormalities in test material. Among these abnormalities were C-mitosis, anaphase bridges, micronuclei, binucleated cells, stickiness, laggards, and chromosome breaks. The nuclear DNA contents decreased when compared with control groups.
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2008.01.043