Age-related elemental change in bones

To investigate age dependence of the bone element contents and structure, lumbar and femur from Sprague–Dawley (SD) rats were chosen for their more susceptibility to fracture. These rats were divided into to 5age groups: 1, 4, 7, 11 and 25month-age, corresponding human beings from the young to the o...

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Published in:Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms Beam interactions with materials and atoms, 2008-04, Vol.266 (8), p.1619-1622
Main Authors: Wang, C., Eisa, M.H., Jin, W., Shen, H., Mi, Y., Gao, J., Zhou, Y., Yao, H., Zhao, Y.
Format: Article
Language:English
Subjects:
Age
Calcium
Osteoporosis
PIXE
Strontium
XAFS
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Summary:To investigate age dependence of the bone element contents and structure, lumbar and femur from Sprague–Dawley (SD) rats were chosen for their more susceptibility to fracture. These rats were divided into to 5age groups: 1, 4, 7, 11 and 25month-age, corresponding human beings from the young to the old. The elements contents were detected by external Proton Induced X-ray emission (PIXE) technique. X-ray Absorption Fine Structure (XAFS) method was also applied to obtain information about calcium (Ca) and phosphor (P) structure. It was found that Ca content, Ca/P ratio, valance state of Ca and P and their coordinate structure remains unaltered with age variance, whereas the content of strontium (Sr) was significantly decreasing. Sr concentration may provide a new parameter for diagnosis of bone disorder.
ISSN:0168-583X
1872-9584
DOI:10.1016/j.nimb.2008.01.015