Candida albicans HSP12 is co-regulated by physiological CO sub(2) and pH

Global transcriptional analysis of Candida albicans exposed to elevated ambient CO sub(2) revealed a statistically significant differential regulation of 14 genes. Subsequent RNA hybridisation analysis of one gene, HSP12, confirmed CO sub(2)-regulation via a cAMP-dependent mechanism. Additionally, N...

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Bibliographic Details
Published in:Fungal genetics and biology 2008-07, Vol.45 (7), p.1075-1080
Main Authors: Sheth, C C, Mogensen, E G, Fu, MS, Blomfield, I C, Muhlschlegel, F A
Format: Article
Language:English
Subjects:
Candida albicans
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Summary:Global transcriptional analysis of Candida albicans exposed to elevated ambient CO sub(2) revealed a statistically significant differential regulation of 14 genes. Subsequent RNA hybridisation analysis of one gene, HSP12, confirmed CO sub(2)-regulation via a cAMP-dependent mechanism. Additionally, Northern analyses and gel mobility shift assays demonstrate the co-regulation of HSP12 by environmental pH via a Rim101-dependent mechanism.
ISSN:1087-1845
DOI:10.1016/j.fgb.2008.04.004