Molecular Hydrogen Prevents Social Deficits and Depression-Like Behaviors Induced by Low-Intensity Blast in Mice

Abstract Detonation of explosive devices creates blast waves, which can injure brains even in the absence of external injuries. Among these, blast-induced mild traumatic brain injury (bmTBI) is increasing in military populations, such as in the wars in Afghanistan, Iraq, and Syria. Although the clin...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuropathology and experimental neurology 2018-09, Vol.77 (9), p.827-836
Main Authors: Satoh, Yasushi, Araki, Yoshiyuki, Kashitani, Masashi, Nishii, Kiyomasa, Kobayashi, Yasushi, Fujita, Masanori, Suzuki, Shinya, Morimoto, Yuji, Tokuno, Shinichi, Tsumatori, Gentaro, Yamamoto, Tetsuo, Saitoh, Daizoh, Ishizuka, Toshiaki
Format: Article
Language:English
Subjects:
Antioxidants (Nutrients)
Brain
Brain injuries
Edema
Explosions
Hydrogen
Laboratory equipment
Morbidity
Novels
Oxidative stress
Social aspects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Detonation of explosive devices creates blast waves, which can injure brains even in the absence of external injuries. Among these, blast-induced mild traumatic brain injury (bmTBI) is increasing in military populations, such as in the wars in Afghanistan, Iraq, and Syria. Although the clinical presentation of bmTBI is not precisely defined, it is frequently associated with psycho-neurological deficits and usually manifests in the form of poly-trauma including psychiatric morbidity and cognitive disruption. Although the underlying mechanisms of bmTBI are largely unknown, some studies suggested that bmTBI is associated with blood-brain barrier disruption, oxidative stress, and edema in the brain. The present study investigated the effects of novel antioxidant, molecular hydrogen gas, on bmTBI using a laboratory-scale shock tube model in mice. Hydrogen gas has a strong prospect for clinical use due to easy preparation, low-cost, and no side effects. The administration of hydrogen gas significantly attenuated the behavioral deficits observed in our bmTBI model, suggesting that hydrogen application might be a strong therapeutic method for treatment of bmTBI.
ISSN:0022-3069
1554-6578
DOI:10.1093/jnen/nly060