Varicella zoster virus cerebral aneurysmal vasculopathy presenting in a newly-diagnosed HIV-positive patient

We report the case of a newly-diagnosed HIV-positive patient with varicella zoster virus aneurysmal vasculopathy confirmed on intrathecal antibody testing, despite a negative Cerebrospinal fluid (CSF) Varicella Zoster Virus (VZV) Polymerase Chain Reaction (PCR). This highlights the importance of pro...

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Bibliographic Details
Published in:International journal of STD & AIDS 2018-11, Vol.29 (13), p.1351-1353
Main Authors: Tomkins, Andrew, Babu, Chitra, Herwadkar, Amit, Siripurapu, Rekha, McKee, David
Format: Article
Language:English
Subjects:
Adult
AIDS/HIV
Anti-Retroviral Agents - administration & dosage
Antiviral Agents - administration & dosage
Brain - blood supply
Brain - diagnostic imaging
Cerebral Arterial Diseases - diagnostic imaging
Computed Tomography Angiography
Encephalitis, Varicella Zoster - complications
Encephalitis, Varicella Zoster - drug therapy
Female
Herpesvirus 3, Human - isolation & purification
HIV Seropositivity - diagnosis
HIV Seropositivity - drug therapy
Humans
Intracranial Aneurysm - diagnostic imaging
Intracranial Hemorrhages - diagnostic imaging
Intracranial Hemorrhages - etiology
Intracranial Hemorrhages - virology
Magnetic Resonance Imaging
Prednisolone - administration & dosage
Treatment Outcome
Varicella Zoster Virus Infection - diagnosis
Varicella Zoster Virus Infection - drug therapy
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Description
Summary:We report the case of a newly-diagnosed HIV-positive patient with varicella zoster virus aneurysmal vasculopathy confirmed on intrathecal antibody testing, despite a negative Cerebrospinal fluid (CSF) Varicella Zoster Virus (VZV) Polymerase Chain Reaction (PCR). This highlights the importance of prompt treatment with antiviral and steroid therapy in the presence of clinical or radiological suspicion whilst awaiting further confirmatory testing.
ISSN:0956-4624
1758-1052
DOI:10.1177/0956462418786334