A comparative analysis of articular bone in large cohort of patients with chronic inflammatory diseases of the joints, the gut and the skin

• Published in: Bone (New York, N.Y.) N.Y.), 2018-11, Vol.116, p.87-93
• Main Authors: Simon, David, Kleyer, Arnd, Englbrecht, Matthias, Stemmler, Fabian, Simon, Christoph, Berlin, Andreas, Kocijan, Roland, Haschka, Judith, Hirschmann, Simon, Atreya, Raja, Neurath, Markus F., Sticherling, Michael, Rech, Juergen, Hueber, Axel J., Engelke, Klaus, Schett, Georg
• Format: Article
• Language: English
• Subjects: Arthritis; Bone and Bones - pathology; Bone Density; Case-Control Studies; Chronic Disease; Cohort Studies; Colitis; Gastrointestinal Tract - pathology; Humans; Inflammation - pathology; Inflammatory bone loss; Joints - pathology; Linear Models; Male; Middle Aged; Peripheral quantitative computed tomography; Psoriasis; Skin - pathology
• ISSN: 8756-3282; 1873-2763
• DOI: 10.1016/j.bone.2018.07.017

Chronic inflammatory diseases are associated with bone loss. While the occurrence of systemic bone loss is well described in chronic inflammatory diseases, the impact of these conditions on articular bone has not been systematically investigated. Recent refinements in high-resolution CT assessment of the joints now allow the accurate measure of articular bone composition. In this study 476 subjects comprising healthy individuals and patients with anticitrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA), ACPA-negative RA, Crohn's disease (CD), ulcerative colitis (UC), psoriasis (PsO) and psoriatic arthritis (PsA) were subjected to high-resolution quantitative computed tomography (HR-pQCT) of the hand. Metacarpal heads were assessed for total, trabecular and cortical volumetric bone mineral density (vBMD). Only ACPA+RA, but not the remaining inflammatory diseases (ACPA−RA, CD, UC, PsO, PsA) showed significant (p