Use of toxicity assays for enantiomeric discrimination of pharmaceutical substances

Toxicity assays are commonly used as general indicators of environmental water pollution. In the study described here, selected toxicity tests have been used to evaluate the different toxicity levels of enantiomers of different pharmaceutical drugs that can be found as potential contaminants in wate...

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Bibliographic Details
Published in:Chirality (New York, N.Y.) N.Y.), 2009-08, Vol.21 (8), p.751-759
Main Authors: De Andres, Fernando, Castaneda, Gregorio, Rios, Angel
Format: Article
Language:English
Subjects:
Animals
Assaying
Atenolol - toxicity
Chirality
Chlorophyta - chemistry
Contaminants
Daphnia magna
Dihydroxyphenylalanine - toxicity
Dopa
enantiomeric effects
Enantiomers
Eukaryota - chemistry
Fluoxetine - toxicity
Freshwater
Isomers
Molecular Structure
pharmaceutical drugs
Pharmaceuticals
Pseudokirchneriella subcapitata
Stereoisomerism
stereoselective toxicity
Tetrahymena thermophila
Toxicity
toxicity assays
Toxicity Tests
Toxins, Biological
water environments
Water Pollutants, Chemical - toxicity
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Summary:Toxicity assays are commonly used as general indicators of environmental water pollution. In the study described here, selected toxicity tests have been used to evaluate the different toxicity levels of enantiomers of different pharmaceutical drugs that can be found as potential contaminants in water environments. Isomers of dopa, fluoxetine, and atenolol were tested with three aquatic organisms corresponding to different trophic levels: Daphnia magna (a crustacean), Pseudokirchneriella subcapitata (a microalga), and Tetrahymena thermophila (a protozoan). Different levels of toxicity were observed for each enantiomer, suggesting that significant enantioselectivity occurs in aquatic toxicity and that such enantiomeric differences must be considered when evaluating the ecological effects of these compounds. Chirality, 2009. © 2008 Wiley‐Liss, Inc.
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.20675