Effect of immunomodulation with levamisole on the course and pathogenesis of acute experimental Trypanosoma congolense infection in sheep

The effect of immunomodulation with levamisole on the pathogenesis and course of acute experimental Trypanosoma congolense infection in sheep was studied. Eighteen Yankasa sheep were divided into three groups: Group A- six (T. congolense infected), Group B- seven (T. congolense infected, immunomodul...

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Bibliographic Details
Published in:African journal of biotechnology 2009-03, Vol.8 (5), p.827-834
Main Authors: Bisalla, M, Adamu, S, Ibrahim, ND-G, Lawal, IA, Esievo, KAN
Format: Article
Language:English
Subjects:
Trypanosoma
Trypanosoma congolense
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Summary:The effect of immunomodulation with levamisole on the pathogenesis and course of acute experimental Trypanosoma congolense infection in sheep was studied. Eighteen Yankasa sheep were divided into three groups: Group A- six (T. congolense infected), Group B- seven (T. congolense infected, immunomodulated) and Group C-five (uninfected controls). Groups A and B sheep were each infected with approximately 2x10 super(6) trypanosomes. In addition, group B sheep were each administered 2.5 mg/kg levamisole hydrochloride subcutaneously on the day of infection and later weekly throughout the experimental period. Clinical signs, appearance and level of parasitemia, PCV, rectal temperatures, total and differential leukocyte counts and body weights were monitored. Clinical signs observed were pale mucous membranes (anaemia), weakness and rough hair coats which were milder in group B sheep. Group B sheep became parasitemic two days earlier than group A and maintained a higher parasitemia at the first peak. The mean PCV decreased significantly (p
ISSN:1684-5315
1684-5315