Bioactive Macrolides and Polyketides from Marine Dinoflagellates of the Genus Amphidinium

Marine microorganisms such as bacteria, cyanobacteria, dinoflagellates, and others have attracted many natural product chemists as the real producers of marine toxins such as fish and algal poisons as well as bioactive substances isolated from marine invertebrates such as sponges and tunicates. Amon...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2007-03, Vol.70 (3), p.451-460
Main Authors: Kobayashi, Jun'ichi, Kubota, Takaaki
Format: Article
Language:English
Subjects:
Amphidinium
Animals
Biological and medical sciences
Cyanobacteria
Dinoflagellida - chemistry
Dinoflagellida - genetics
General pharmacology
Macrolides - isolation & purification
Marine Biology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
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Summary:Marine microorganisms such as bacteria, cyanobacteria, dinoflagellates, and others have attracted many natural product chemists as the real producers of marine toxins such as fish and algal poisons as well as bioactive substances isolated from marine invertebrates such as sponges and tunicates. Among marine microorganisms, dinoflagellates have proved to be important sources of marine toxins and have been investigated worldwide by natural product chemists. We have continued investigations on chemically interesting and biologically significant secondary metabolites from Amphidinium spp., of a genus of symbiotic marine dinoflagellates separated from inside cells of Okinawan marine flatworms. This review covers the results described in our recent publications on a series of cytotoxic macrolides, designated amphidinolides, and long-chain polyketides isolated from Amphidinium spp. In this review, topics include the isolation, structure elucidation, synthesis, biosynthesis, and bioactivity of amphidinolides and long-chain polyketides.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0605844