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Efficacy of Follow-up Care System of Living Kidney Donors in Monitoring of Residual Kidney Function
The possibility of an increased risk of end-stage renal disease is a major concern associated with living kidney donation. Therefore, monitoring of residual kidney function becomes most essential. A data analysis of 156 living kidney donors (LKDs) was conducted. The efficacy of the long-term care sy...
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| Published in: | Transplantation proceedings 2018-07, Vol.50 (6), p.1590-1596 |
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| container_end_page | 1596 |
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| container_title | Transplantation proceedings |
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| creator | Kwapisz, M. Kieszek, R. Jędrzejko, K. Bieniasz, M. Gozdowska, J. Kwiatkowski, A. |
| description | The possibility of an increased risk of end-stage renal disease is a major concern associated with living kidney donation. Therefore, monitoring of residual kidney function becomes most essential.
A data analysis of 156 living kidney donors (LKDs) was conducted. The efficacy of the long-term care system with regard to monitoring residual kidney function was evaluated.
The analyzed group consisted of 102 (65.4%) women. The mean follow-up period was 5.44 years. The rise in value of mean serum creatinine concentration after donation was observed, but it was within the range of normal during the observation period. Despite its initial decline after nephrectomy, mean glomerular filtration rate (GFR) remained >60 mL/min/1.73 m2. A MDRD (Modification of Diet in Renal Disease) GFR in the range of 45–60 mL/min/1.73 m2 was observed in 53 donors (33.97%). It was found to be |
| doi_str_mv | 10.1016/j.transproceed.2018.02.115 |
| format | article |
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A data analysis of 156 living kidney donors (LKDs) was conducted. The efficacy of the long-term care system with regard to monitoring residual kidney function was evaluated.
The analyzed group consisted of 102 (65.4%) women. The mean follow-up period was 5.44 years. The rise in value of mean serum creatinine concentration after donation was observed, but it was within the range of normal during the observation period. Despite its initial decline after nephrectomy, mean glomerular filtration rate (GFR) remained >60 mL/min/1.73 m2. A MDRD (Modification of Diet in Renal Disease) GFR in the range of 45–60 mL/min/1.73 m2 was observed in 53 donors (33.97%). It was found to be <45.0 mL/min/1.73 m2 in 15 cases (9.6%). No patient developed end-stage renal disease. Only 25.0% of those analyzed had their CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) GFR estimated on 45–60 mL/min/1.73 m2 and 4.49% were found to have levels of <45 mL/min/1.73 m2 (down to 33.7 mL/min/1.73 m2). Mean postdonation CKD-EPI GFR was estimated at 69.99% of its predonation value.
A reliable qualification process could minimize the probability of kidney donation by someone with an increased risk of chronic kidney failure. The CKD-EPI formula seems to be more precise than the MDRD for estimatation of LKDs' GFR, as their loss of GFR is a result of nephrectomy and not kidney or systemic disease. Using the MDRD formula may lead to inappropriate diagnosis of CKD in some cases.
•Monitoring of residual kidney function is a main purpose of follow-up care for living kidney donors.•The Chronic Kidney Disease Epidemiology Collaboration formula is more precise than the Modification of Diet in Renal Disease (MDRD) formula in living kidney donors.•Estimation of glomerular filtration rate using the MDRD may lead to inappropriate diagnosis of kidney disease.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2018.02.115</identifier><identifier>PMID: 30056866</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aftercare - methods ; Aged ; Creatinine - blood ; Female ; Glomerular Filtration Rate ; Humans ; Kidney - physiopathology ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - prevention & control ; Kidney Transplantation ; Living Donors ; Male ; Middle Aged ; Nephrectomy - adverse effects ; Nephrectomy - rehabilitation ; Postoperative Complications - etiology ; Postoperative Complications - prevention & control ; Postoperative Period ; Tissue and Organ Harvesting - adverse effects ; Tissue and Organ Harvesting - methods ; Tissue and Organ Harvesting - rehabilitation ; Treatment Outcome ; Young Adult</subject><ispartof>Transplantation proceedings, 2018-07, Vol.50 (6), p.1590-1596</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c323t-cf795fb1f4bd0f476753ec423655e36c600bb86fc6b6aa25ed9be8807417721f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30056866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwapisz, M.</creatorcontrib><creatorcontrib>Kieszek, R.</creatorcontrib><creatorcontrib>Jędrzejko, K.</creatorcontrib><creatorcontrib>Bieniasz, M.</creatorcontrib><creatorcontrib>Gozdowska, J.</creatorcontrib><creatorcontrib>Kwiatkowski, A.</creatorcontrib><title>Efficacy of Follow-up Care System of Living Kidney Donors in Monitoring of Residual Kidney Function</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>The possibility of an increased risk of end-stage renal disease is a major concern associated with living kidney donation. Therefore, monitoring of residual kidney function becomes most essential.
A data analysis of 156 living kidney donors (LKDs) was conducted. The efficacy of the long-term care system with regard to monitoring residual kidney function was evaluated.
The analyzed group consisted of 102 (65.4%) women. The mean follow-up period was 5.44 years. The rise in value of mean serum creatinine concentration after donation was observed, but it was within the range of normal during the observation period. Despite its initial decline after nephrectomy, mean glomerular filtration rate (GFR) remained >60 mL/min/1.73 m2. A MDRD (Modification of Diet in Renal Disease) GFR in the range of 45–60 mL/min/1.73 m2 was observed in 53 donors (33.97%). It was found to be <45.0 mL/min/1.73 m2 in 15 cases (9.6%). No patient developed end-stage renal disease. Only 25.0% of those analyzed had their CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) GFR estimated on 45–60 mL/min/1.73 m2 and 4.49% were found to have levels of <45 mL/min/1.73 m2 (down to 33.7 mL/min/1.73 m2). Mean postdonation CKD-EPI GFR was estimated at 69.99% of its predonation value.
A reliable qualification process could minimize the probability of kidney donation by someone with an increased risk of chronic kidney failure. The CKD-EPI formula seems to be more precise than the MDRD for estimatation of LKDs' GFR, as their loss of GFR is a result of nephrectomy and not kidney or systemic disease. Using the MDRD formula may lead to inappropriate diagnosis of CKD in some cases.
•Monitoring of residual kidney function is a main purpose of follow-up care for living kidney donors.•The Chronic Kidney Disease Epidemiology Collaboration formula is more precise than the Modification of Diet in Renal Disease (MDRD) formula in living kidney donors.•Estimation of glomerular filtration rate using the MDRD may lead to inappropriate diagnosis of kidney disease.</description><subject>Adult</subject><subject>Aftercare - methods</subject><subject>Aged</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Kidney - physiopathology</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Kidney Failure, Chronic - prevention & control</subject><subject>Kidney Transplantation</subject><subject>Living Donors</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nephrectomy - adverse effects</subject><subject>Nephrectomy - rehabilitation</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - prevention & control</subject><subject>Postoperative Period</subject><subject>Tissue and Organ Harvesting - adverse effects</subject><subject>Tissue and Organ Harvesting - methods</subject><subject>Tissue and Organ Harvesting - rehabilitation</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqNkFFr2zAQx8XoWNJsX2GYPfXF3kmyZbtvI23a0YxC1z4LWT4VBUfKJLsl374KaWCPfTqO_-_uuB8hPygUFKj4uSnGoFzcBa8R-4IBbQpgBaXVJzKnTc1zJhg_I3OAkuaUl9WMnMe4gdSzkn8hMw5QiUaIOdHXxlit9D7zJlv5YfCv-bTLlipg9ncfR9wegrV9se45u7O9w3125Z0PMbMu--OdHX04ZIl6wGj7SQ0nbjU5PVrvvpLPRg0Rv73XBXlaXT8ub_P1_c3v5a91rjnjY65N3Vamo6bsejBlLeqKoy4ZF1WFXGgB0HWNMFp0QilWYd922DRQl7SuGTV8QS6Oe5OZfxPGUW5t1DgMyqGfomRQt20pWgYJvTyiOvgYAxq5C3arwl5SkAfJciP_lywPkiUwmSSn4e_vd6Zum7LT6MlqAq6OAKZvXywGGbVFp7G3AfUoe28_cucNxfWU_Q</recordid><startdate>201807</startdate><enddate>201807</enddate><creator>Kwapisz, M.</creator><creator>Kieszek, R.</creator><creator>Jędrzejko, K.</creator><creator>Bieniasz, M.</creator><creator>Gozdowska, J.</creator><creator>Kwiatkowski, A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201807</creationdate><title>Efficacy of Follow-up Care System of Living Kidney Donors in Monitoring of Residual Kidney Function</title><author>Kwapisz, M. ; Kieszek, R. ; Jędrzejko, K. ; Bieniasz, M. ; Gozdowska, J. ; Kwiatkowski, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-cf795fb1f4bd0f476753ec423655e36c600bb86fc6b6aa25ed9be8807417721f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aftercare - methods</topic><topic>Aged</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Kidney - physiopathology</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Kidney Failure, Chronic - prevention & control</topic><topic>Kidney Transplantation</topic><topic>Living Donors</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nephrectomy - adverse effects</topic><topic>Nephrectomy - rehabilitation</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - prevention & control</topic><topic>Postoperative Period</topic><topic>Tissue and Organ Harvesting - adverse effects</topic><topic>Tissue and Organ Harvesting - methods</topic><topic>Tissue and Organ Harvesting - rehabilitation</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwapisz, M.</creatorcontrib><creatorcontrib>Kieszek, R.</creatorcontrib><creatorcontrib>Jędrzejko, K.</creatorcontrib><creatorcontrib>Bieniasz, M.</creatorcontrib><creatorcontrib>Gozdowska, J.</creatorcontrib><creatorcontrib>Kwiatkowski, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwapisz, M.</au><au>Kieszek, R.</au><au>Jędrzejko, K.</au><au>Bieniasz, M.</au><au>Gozdowska, J.</au><au>Kwiatkowski, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Follow-up Care System of Living Kidney Donors in Monitoring of Residual Kidney Function</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2018-07</date><risdate>2018</risdate><volume>50</volume><issue>6</issue><spage>1590</spage><epage>1596</epage><pages>1590-1596</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><abstract>The possibility of an increased risk of end-stage renal disease is a major concern associated with living kidney donation. Therefore, monitoring of residual kidney function becomes most essential.
A data analysis of 156 living kidney donors (LKDs) was conducted. The efficacy of the long-term care system with regard to monitoring residual kidney function was evaluated.
The analyzed group consisted of 102 (65.4%) women. The mean follow-up period was 5.44 years. The rise in value of mean serum creatinine concentration after donation was observed, but it was within the range of normal during the observation period. Despite its initial decline after nephrectomy, mean glomerular filtration rate (GFR) remained >60 mL/min/1.73 m2. A MDRD (Modification of Diet in Renal Disease) GFR in the range of 45–60 mL/min/1.73 m2 was observed in 53 donors (33.97%). It was found to be <45.0 mL/min/1.73 m2 in 15 cases (9.6%). No patient developed end-stage renal disease. Only 25.0% of those analyzed had their CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) GFR estimated on 45–60 mL/min/1.73 m2 and 4.49% were found to have levels of <45 mL/min/1.73 m2 (down to 33.7 mL/min/1.73 m2). Mean postdonation CKD-EPI GFR was estimated at 69.99% of its predonation value.
A reliable qualification process could minimize the probability of kidney donation by someone with an increased risk of chronic kidney failure. The CKD-EPI formula seems to be more precise than the MDRD for estimatation of LKDs' GFR, as their loss of GFR is a result of nephrectomy and not kidney or systemic disease. Using the MDRD formula may lead to inappropriate diagnosis of CKD in some cases.
•Monitoring of residual kidney function is a main purpose of follow-up care for living kidney donors.•The Chronic Kidney Disease Epidemiology Collaboration formula is more precise than the Modification of Diet in Renal Disease (MDRD) formula in living kidney donors.•Estimation of glomerular filtration rate using the MDRD may lead to inappropriate diagnosis of kidney disease.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30056866</pmid><doi>10.1016/j.transproceed.2018.02.115</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aftercare - methods Aged Creatinine - blood Female Glomerular Filtration Rate Humans Kidney - physiopathology Kidney Failure, Chronic - etiology Kidney Failure, Chronic - prevention & control Kidney Transplantation Living Donors Male Middle Aged Nephrectomy - adverse effects Nephrectomy - rehabilitation Postoperative Complications - etiology Postoperative Complications - prevention & control Postoperative Period Tissue and Organ Harvesting - adverse effects Tissue and Organ Harvesting - methods Tissue and Organ Harvesting - rehabilitation Treatment Outcome Young Adult |
| title | Efficacy of Follow-up Care System of Living Kidney Donors in Monitoring of Residual Kidney Function |
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