Synthesis, characterization and evaluation of antibacterial activity of copper oxide nanoparticles against clinical strains of Staphylococcus aureus

Bacterial resistance is spreading globally due to excessive use of antibiotics, making it one of our times biggest challenges. To address this issue present study was conducted to evaluate the antibacterial activity of copper oxide nanoparticles against methicillin-resistant S. aureus (MRSA). Copper...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2018-07, Vol.31 (4(Supplementary)), p.1549-1553
Main Authors: Niaz, Naheed, Bano, Asma, Fasim, Fehmida, Kausar, Rehana, Khan, Barkat Ali, Zafar, Naheed, Khan, Samiullah, Uzair, Bushra
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Copper - chemistry
Copper - pharmacology
Drug Evaluation, Preclinical - methods
Humans
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - chemistry
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - physiology
Microbial Sensitivity Tests - methods
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Summary:Bacterial resistance is spreading globally due to excessive use of antibiotics, making it one of our times biggest challenges. To address this issue present study was conducted to evaluate the antibacterial activity of copper oxide nanoparticles against methicillin-resistant S. aureus (MRSA). Copper oxide nanoparticles were synthesized by chemical precipitation method and were characterized by UV-Visible, FT-IR spectroscopy, X-ray diffraction (XRD) and Scanning Electron Microscopy. These nanoparticles of 27nm were assessed for antibacterial activity using disc diffusion method. Our results showed superb inhibitory effects of CuO nanoparticles with increase in concentration and complete inhibition was recorded against tested strains of S. aureus at 100μl/ml and 125μl/ml concentration. The study concludes that the drugs which do not show any inhibitory effects against resistant bugs could be augmented with CuO nanoparticles to achieve the treatment goal.
ISSN:1011-601X