Optical Analysis of Reaction Yield and Enantiomeric Excess: A New Paradigm Ready for Prime Time

This Perspective highlights the advances of optical methods for asymmetric reaction discovery. Optical analysis allows for the determination of absolute configuration, enantiomeric excess and reaction yield that is amenable to high-throughput experimentation. Thus, the synthetic organic community is...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2018-08, Vol.140 (33), p.10385-10401
Main Authors: Herrera, Brenden T, Pilicer, Samantha L, Anslyn, Eric V, Joyce, Leo A, Wolf, Christian
Format: Article
Language:English
Subjects:
Catalysis
Chromatography, High Pressure Liquid
Circular Dichroism
Colorimetry - methods
High-Throughput Screening Assays
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Optical Imaging
Organic Chemicals - chemistry
Particle Size
Spectrophotometry, Ultraviolet
Stereoisomerism
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Summary:This Perspective highlights the advances of optical methods for asymmetric reaction discovery. Optical analysis allows for the determination of absolute configuration, enantiomeric excess and reaction yield that is amenable to high-throughput experimentation. Thus, the synthetic organic community is encouraged to incorporate the methods discussed to expedite the development of high-yielding, enantioselective transformations.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.8b06607