Genome‐wide association study of body morphological traits in Sudanese goats

Summary Long‐term selection of goats for a certain production system and/or different environmental conditions will be reflected in the body morphology of the animals under selection. To investigate the variation contributing to different morphological traits and to identify genomic regions that are...

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Bibliographic Details
Published in:Animal genetics 2018-10, Vol.49 (5), p.478-482
Main Authors: Rahmatalla, S. A., Arends, D., Reissmann, M., Wimmers, K., Reyer, H., Brockmann, G. A.
Format: Article
Language:English
Subjects:
Alleles
Animals
Body Height
Body length
Body Size
Caprinae
Chromosome 2
Chromosome 3
Chromosomes
Desert goat
Environmental conditions
Females
Genes
Genome-wide association studies
Genome-Wide Association Study
Genomes
goat morphology
Goat SNP52 BeadChip
Goats
Goats - anatomy & histology
Goats - classification
Goats - genetics
Humans
Morphology
Nilotic goat
Nubian goat
Polymorphism, Single Nucleotide
Quality control
Quantitative trait loci
Single-nucleotide polymorphism
Taggar goat
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Summary:Summary Long‐term selection of goats for a certain production system and/or different environmental conditions will be reflected in the body morphology of the animals under selection. To investigate the variation contributing to different morphological traits and to identify genomic regions that are associated with body morphological traits in Sudanese goats, we genotyped 96 females belonging to four Sudanese goat breeds with the SNP52 BeadChip. After quality control of the data, the genome‐wide association study was performed using 95 goats and 24 027 informative single nucleotide polymorphisms (SNPs). Bicoastal diameter was significantly associated (LOD = 6.32) with snp10185‐scaffold1365‐620922 on chromosome 2. The minor allele has an additive effect, increasing the bicoastal diameter by 2.6 cm. A second significant association was found between body length and snp56482‐scaffold89‐467312 on chromosome 3 (LOD = 5.65). The minor allele is associated with increased body length. Additionally, five regions were suggestive for cannon bone, head width, rump length and withers height (LOD > 5). Only one gene (CNTNAP5) is located within the 1‐Mb region surrounding the significant SNP for bicoastal diameter on chromosome 2. The body length QTL on chromosome 3 harbors 49 genes. Further research is required to validate the observed associations and to prioritize candidate genes.
ISSN:0268-9146
1365-2052
DOI:10.1111/age.12686