Preoperative diagnosis of a giant cell tumor of soft tissue arising from the breast by ultrasound-guided core needle biopsy

Giant cell tumors of soft tissue (GCT-ST) arising in the breast are extremely rare. Herein, we report a case of a 45-year-old woman with a 5-cm mass in her left breast. Ultrasonography revealed a mainly well-circumscribed mass that contained a cystic lesion. Magnetic resonance imaging showed a fibro...

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Bibliographic Details
Published in:Journal of medical ultrasonics (2001) 2019-04, Vol.46 (2), p.257-261
Main Authors: Sawa, Aya, Ikeda, Tatsuhiko, Ichioka, Emika, Tsushima, Yukiko, Iguchi-Manaka, Akiko, Bando, Hiroko, Kondo, Yuzuru, Hara, Hisato
Format: Article
Language:English
Subjects:
Biopsy
Breast
Cancer
Case Report
Conflicts of interest
Diagnosis
Diagnostic imaging
Ethics
Exocrine glands
Females
Hemorrhage
Imaging
Larynx
Lymphatic system
Magnetic resonance imaging
Mastectomy
Medicine
Medicine & Public Health
Metastasis
Patients
Radiology
Soft tissues
Staining
Thyroid gland
Tumors
Ultrasonic imaging
Ultrasound
Ultrasound imaging
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Summary:Giant cell tumors of soft tissue (GCT-ST) arising in the breast are extremely rare. Herein, we report a case of a 45-year-old woman with a 5-cm mass in her left breast. Ultrasonography revealed a mainly well-circumscribed mass that contained a cystic lesion. Magnetic resonance imaging showed a fibrous capsule-covered mass that contained a high-intensity area, suggesting hemorrhaging. Ultrasound-guided core needle biopsy (CNB) revealed mononuclear histiocytic cells with a round shape or spindled appearance that was mixed with multinucleated giant cells. Immunohistochemical analysis revealed CD68-positive staining in the mononuclear and giant cells but negative staining for pancytokeratin. Preoperatively, the tumor was highly suspected of being GCT-ST. Histopathological results after a left mastectomy showed similar findings to CNB. The final diagnosis was GCT-ST in the breast. To the best of our knowledge, this is the first case report of a GCT-ST arising in the breast diagnosed by ultrasound-guided CNB.
ISSN:1346-4523
1613-2254
DOI:10.1007/s10396-018-0891-0