Association of Native American ancestry and common variants in ACE, ADIPOR2, MTNR1B, GCK, TCF7L2 and FTO genes with glycemic traits in Colombian population

Insulin resistance and defects in other related glycemic traits are common findings in the context of Metabolic Syndrome. Although genetic factors are clearly implied in susceptibility, and some gene variants have been identified mainly in populations of European ancestry, little is known about this...

Full description

Saved in:
Bibliographic Details
Published in:Gene 2018-11, Vol.677, p.198-210
Main Authors: Caro-Gomez, María Antonieta, Naranjo-González, Carlos Andrés, Gallego-Lopera, Natalia, Parra-Marín, María Victoria, Valencia, Diana María, Arcos, Edgar Gerardo, Villegas-Perrasse, Alberto, Bedoya-Berrío, Gabriel
Format: Article
Language:English
Subjects:
Fasting glucose
Fasting insulin
Genetic ancestry
HOMA
Insulin resistance
β-Cell
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Insulin resistance and defects in other related glycemic traits are common findings in the context of Metabolic Syndrome. Although genetic factors are clearly implied in susceptibility, and some gene variants have been identified mainly in populations of European ancestry, little is known about this aspect in admixed populations. The association of insulin resistance, β-cell function, fasting insulin and glucose levels with 48 gene variants, previously related to metabolic syndrome components, and with the ancestral genetic composition, estimated on 50 ancestry informative markers, was evaluated in 417 individuals from the Colombian admixed population. The Native American genetic ancestry was associated with a low β-cell function (odds ratio (OR) of 1.73 and 95% confidence interval (95% CI) of 1.07–2.81, p = 0.026). Significant genotypic associations were obtained (q-value 
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2018.07.066