Release of multifunctional peptides from kiwicha (Amaranthus caudatus) protein under in vitro gastrointestinal digestion

BACKGROUND The multifactorial origin of many chronic diseases provides a new framework for the development of multifunctional foods. In this study, the effect of in vitro simulated gastrointestinal digestion of kiwicha (Amaranthus caudatus) proteins on the release of multifunctional peptides was eva...

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Bibliographic Details
Published in:Journal of the science of food and agriculture 2019-02, Vol.99 (3), p.1225-1232
Main Authors: Vilcacundo, Rubén, Martínez‐Villaluenga, Cristina, Miralles, Beatriz, Hernández‐Ledesma, Blanca
Format: Article
Language:English
Subjects:
Amaranth
Amaranthus caudatus
Amylases
Angiotensin
Angiotensin I
Antioxidants
bioactive peptides
Chronic illnesses
Colon
Colon cancer
Diabetes mellitus
Digestion
Digestive system
Dipeptidyl-peptidase IV
Functional foods & nutraceuticals
Gastrointestinal tract
Hypertension
kiwicha
multifunctional activity
Organic chemistry
Oxidative stress
Peptidase
Peptides
Proteins
simulated gastrointestinal digestion
α-Amylase
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Summary:BACKGROUND The multifactorial origin of many chronic diseases provides a new framework for the development of multifunctional foods. In this study, the effect of in vitro simulated gastrointestinal digestion of kiwicha (Amaranthus caudatus) proteins on the release of multifunctional peptides was evaluated. RESULTS Gastric digest showed higher angiotensin I converting enzyme (ACE) inhibitory activity while 60 min gastroduodenal digest showed the highest antioxidant, dipeptidyl peptidase IV (DPP‐IV), α‐amylase and Caco‐2 cell viability inhibitory activities. Peptides >5 kDa were more effective in inhibiting colon cancer cell viability, whereas peptides
ISSN:0022-5142
1097-0010
DOI:10.1002/jsfa.9294