Concussion Incidence and Recovery of Neurocognitive Dysfunction Among Youth Athletes Taking Antibiotics: A Preliminary, Multicenter Retrospective Cohort Study

Concussions are the leading cause of injury among youth athletes, and antibiotics are the most prescribed pediatric medication in the United States. Antibiotics have shown to exert neuroprotective effects in animal models of traumatic brain injury, but to date, no human studies exist. Between 2009 a...

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Published in:International journal of athletic therapy & training 2024-01, Vol.29 (1), p.38-44
Main Authors: Asghar, Nek, Ali, Muhammad, Hannah, Theodore, Li, Adam Y., Asfaw, Zerubabbel, Hrabarchuk, Eugene I., Quinones, Addison, McCarthy, Lily, Vasan, Vikram, Murtaza-Ali, Muhammad, Lin, Anthony, Alasadi, Husni, Nakadar, Zaid, Schupper, Alexander J., Gometz, Alex, Lovell, Mark R., Choudhri, Tanvir F.
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container_issue 1
container_start_page 38
container_title International journal of athletic therapy & training
container_volume 29
creator Asghar, Nek
Ali, Muhammad
Hannah, Theodore
Li, Adam Y.
Asfaw, Zerubabbel
Hrabarchuk, Eugene I.
Quinones, Addison
McCarthy, Lily
Vasan, Vikram
Murtaza-Ali, Muhammad
Lin, Anthony
Alasadi, Husni
Nakadar, Zaid
Schupper, Alexander J.
Gometz, Alex
Lovell, Mark R.
Choudhri, Tanvir F.
description Concussions are the leading cause of injury among youth athletes, and antibiotics are the most prescribed pediatric medication in the United States. Antibiotics have shown to exert neuroprotective effects in animal models of traumatic brain injury, but to date, no human studies exist. Between 2009 and 2019, 6,343 adolescent athletes with differential antibiotic use at baseline were administered Immediate Post-concussion Assessment and Cognitive Testing at baseline and twice postinjury. Chronic antibiotic use was associated with a reduced risk for concussion (odds ratio 0.54), increased postconcussive symptomology and neurocognitive burden, and improved recovery by follow-up, a median of 7 days after concussion. This preliminary retrospective analysis suggests antibiotic use may impart neuroprotection up to a certain severity threshold, leading to fewer, yet more severe concussions that tend to recover faster.
doi_str_mv 10.1123/ijatt.2022-0111
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title Concussion Incidence and Recovery of Neurocognitive Dysfunction Among Youth Athletes Taking Antibiotics: A Preliminary, Multicenter Retrospective Cohort Study
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