Antiplasmodial b-hydroxydihydrochalcone from seedpods of Tephrosia elata

From the seedpods of Tephrosia elata, a new b-hydroxydihydrochalcone named (S)- elatadihydrochalcone was isolated. In addition, the known flavonoids obovatachalcone, obovatin, obovatin methyl ether and deguelin were identified. The structures were determined on the basis of spectroscopic evidence. T...

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Bibliographic Details
Published in:Phytochemistry letters 2009-08, Vol.2 (3), p.99-102
Main Authors: Muiva, Lois M, Yenesew, Abiy, Derese, Solomon, Heydenreich, Matthias, Peter, Martin G, Akala, Hoseah M, Eyase, Fredrick, Waters, Norman C, Mutai, Charles, Keriko, Joseph M, Walsh, Douglas
Format: Article
Language:English
Subjects:
Tephrosia
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Summary:From the seedpods of Tephrosia elata, a new b-hydroxydihydrochalcone named (S)- elatadihydrochalcone was isolated. In addition, the known flavonoids obovatachalcone, obovatin, obovatin methyl ether and deguelin were identified. The structures were determined on the basis of spectroscopic evidence. The crude extract and the flavonoids obtained from the seedpods of this plant showed antiplasmodial activities. The literature NMR data on b-hydroxydihydrochalcones is reviewed and the identity of some of the compounds assigned b-hydroxydihydrochalcone skeleton is questioned.
ISSN:1874-3900
DOI:10.1016/j.phytol.2009.01.002