Antifeedant C sub(20) Diterpene Alkaloids

We have tested the insect antifeedant and toxic activity of 21 C sub(20) diterpenoid alkaloids on Spodoptera littoralis and Leptinotarsa decemlineata. The antifeedant effects of the test compounds were structure- and species-dependent. The most active antifeedants to L. decemlineata and S. littorali...

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Bibliographic Details
Published in:Chemistry & biodiversity 2004-01, Vol.1 (9), p.1327-1335
Main Authors: Gonzalez-Coloma, Azucena, Reina, Matias, Guadano, Ana, Martinez-Diaz, Rafael, Diaz, Jesus G, Garcia-Rodriguez, Juan, Alva, Allenger, Grandez, Maritza
Format: Article
Language:English
Subjects:
Leptinotarsa decemlineata
Noctuidae
Spodoptera littoralis
Trypanosoma cruzi
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Summary:We have tested the insect antifeedant and toxic activity of 21 C sub(20) diterpenoid alkaloids on Spodoptera littoralis and Leptinotarsa decemlineata. The antifeedant effects of the test compounds were structure- and species-dependent. The most active antifeedants to L. decemlineata and S. littoralis were the rearranged form of hetisine (20; EC sub(50)=1.7 [mu]g/cm super(2)) and 19-oxodihydroatisine (9; EC sub(50)=0.1 [mu]g/cm super(2)), resp. Glandulosine (8) moderately affected orally injected S. littoralis larvae. A few compounds (13-oxocardiopetamine (4), 9, and atisinium chloride (13)) had cytotoxic effects to insect-derived Sf9 cells with varying degrees of selectivity with respect to mammalian CHO cells. Compounds 4 and 15,22-O- diacetyl-19-oxodihydroatisine (10) increased Trypanosoma cruzi mortality. Our results support the plant protective role of C sub(20) diterpenoid alkaloids and open a new field for parasite control strategies.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.200490095