MRI Features and Site-specific Factors of Ischemic Changes in White Matter: A Retrospective Study

Summary Brain magnetic resonance imaging (MRI) of the elderly often reveals white matter changes (WMCs) with substantial variability across individuals. Our study was designed to explore MRI features and site-specific factors of ischemic WMCs. Clinical data of consecutive patients diagnosed with isc...

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Bibliographic Details
Published in:Current medical science 2018-04, Vol.38 (2), p.318-323
Main Authors: Zhang, You-ping, Liu, Na, Liu, Kai-yan, Pan, Chao, Cai, Xuan, Yang, Shi-qi, Tang, Zhou-ping, Xu, Sha-bei
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
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Summary:Summary Brain magnetic resonance imaging (MRI) of the elderly often reveals white matter changes (WMCs) with substantial variability across individuals. Our study was designed to explore MRI features and site-specific factors of ischemic WMCs. Clinical data of consecutive patients diagnosed with ischemic cerebral vascular disease who had undergone brain MRI were collected and analyzed. Multi-logistic regression analysis comparing patients with mild versus severe WMCs was performed to detect independent associations. Analyses of variance (ANOVAs) were used to detect regionally specific differences in lesions. We found that lesion distribution differed significantly across five cerebral areas, with lesions being predominant in the frontal lobe and parieto-occipital area. To explore WMCs risk factors, after adjusting for gender, diabetes mellitus, and hypertension, only age ( P
ISSN:2096-5230
2523-899X
DOI:10.1007/s11596-018-1881-6