Loading…
Split-Face, Randomized, Placebo-Controlled, Double-Blind Study to Investigate Passive Versus Active Dermal Filler Administration
Background QueryHyaluronic acid (HA) is a large polymer increasingly used as dermal filler. HA does not permeate through healthy skin and is administered using various injection techniques. As HA procedures become more popular, the number of complications in facial rejuvenation procedures is likely...
Saved in:
| Published in: | Aesthetic plastic surgery 2018-12, Vol.42 (6), p.1655-1663 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c372t-620b4cc640852c0718446e2b38feebdc7240b334184b755c66c99340856a23a03 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c372t-620b4cc640852c0718446e2b38feebdc7240b334184b755c66c99340856a23a03 |
| container_end_page | 1663 |
| container_issue | 6 |
| container_start_page | 1655 |
| container_title | Aesthetic plastic surgery |
| container_volume | 42 |
| creator | Freire dos Santos, Mário Jorge Carvalho, Ricardo Arnaut, Luis G. |
| description | Background
QueryHyaluronic acid (HA) is a large polymer increasingly used as dermal filler. HA does not permeate through healthy skin and is administered using various injection techniques. As HA procedures become more popular, the number of complications in facial rejuvenation procedures is likely to increase. Alternative methods may be necessary to satisfy the increasing demand for HA procedures. High-frequency high-intensity ultrasound is a painless and noninvasive method to deliver large molecules to the skin that is expected to deliver HA with visible results.
Objective
Assess facial rejuvenation with HA delivered with high-frequency high-intensity ultrasound.
Methods
Fifteen women (mean age 55) willing to participate in a randomized, double-blind, face-split trial with HA and placebo formulations in different sides of the face, were subject to five treatment sessions with high-frequency high-intensity ultrasound. Photographs taken before the procedure and after the last procedure were evaluated by a panel of five experts, blind to which side was treated with the HA or with the placebo.
Results
The expert panel identified a noticeable facial rejuvenation in the HA side relative to the placebo with a very statistically significant difference between the two sides (
p
|
| doi_str_mv | 10.1007/s00266-018-1208-9 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2083708911</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2083708911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-620b4cc640852c0718446e2b38feebdc7240b334184b755c66c99340856a23a03</originalsourceid><addsrcrecordid>eNp1kU9LHDEYxkOx6Gr9AL2UQC8eTJt_k8wct6vbCkKlVuktZDJZiWSSbZIR9NSP3gxrWyh4Cnnye573JQ8Abwn-QDCWHzPGVAiESYsIxS3qXoEF4YyihnKyBxaYCY4oET8OwGHO9xgTKiXfBwesugXncgF-XW-9K2itjT2F33QY4uie7HAKr3yV-ohWMZQUvZ-1szj13qJP3oUBXpdpeIQlwovwYHNxd7pYeKVzdg8W3tqUpwyXpsy3M5tG7eHa1ZgEl8Pogssl6eJieANeb7TP9vj5PAI36_Pvqy_o8uvni9XyEhkmaUGC4p4bIzhuG2qwJC3nwtKetRtr-8FIynHPGK96L5vGCGG6js200JRpzI7AyS53m-LPqS6sRpeN9V4HG6es6v8xiduOkIq-_w-9j1MKdbuZoqxrOj4Hkh1lUsw52Y3aJjfq9KgIVnM9alePqvWouR7VVc-75-SpH-3w1_GnjwrQHZDrU7iz6d_ol1N_A6HhmYI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2082395940</pqid></control><display><type>article</type><title>Split-Face, Randomized, Placebo-Controlled, Double-Blind Study to Investigate Passive Versus Active Dermal Filler Administration</title><source>Springer Link</source><creator>Freire dos Santos, Mário Jorge ; Carvalho, Ricardo ; Arnaut, Luis G.</creator><creatorcontrib>Freire dos Santos, Mário Jorge ; Carvalho, Ricardo ; Arnaut, Luis G.</creatorcontrib><description>Background
QueryHyaluronic acid (HA) is a large polymer increasingly used as dermal filler. HA does not permeate through healthy skin and is administered using various injection techniques. As HA procedures become more popular, the number of complications in facial rejuvenation procedures is likely to increase. Alternative methods may be necessary to satisfy the increasing demand for HA procedures. High-frequency high-intensity ultrasound is a painless and noninvasive method to deliver large molecules to the skin that is expected to deliver HA with visible results.
Objective
Assess facial rejuvenation with HA delivered with high-frequency high-intensity ultrasound.
Methods
Fifteen women (mean age 55) willing to participate in a randomized, double-blind, face-split trial with HA and placebo formulations in different sides of the face, were subject to five treatment sessions with high-frequency high-intensity ultrasound. Photographs taken before the procedure and after the last procedure were evaluated by a panel of five experts, blind to which side was treated with the HA or with the placebo.
Results
The expert panel identified a noticeable facial rejuvenation in the HA side relative to the placebo with a very statistically significant difference between the two sides (
p
< 0.0001).
Conclusions
Administration of HA with high-frequency high-intensity ultrasound is safe and leads to unambiguous facial rejuvenation.
Level of Evidence I
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</description><identifier>ISSN: 0364-216X</identifier><identifier>EISSN: 1432-5241</identifier><identifier>DOI: 10.1007/s00266-018-1208-9</identifier><identifier>PMID: 30076447</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Cosmetic Techniques ; Dermal fillers ; Dermal Fillers - administration & dosage ; Double-Blind Method ; Double-blind studies ; Esthetics ; Female ; Humans ; Hyaluronic Acid - administration & dosage ; Injections, Subcutaneous ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Otorhinolaryngology ; Patient Satisfaction - statistics & numerical data ; Plastic Surgery ; Rejuvenation - physiology ; Risk Assessment ; Ultrasonic imaging ; Ultrasonography</subject><ispartof>Aesthetic plastic surgery, 2018-12, Vol.42 (6), p.1655-1663</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2018</rights><rights>Aesthetic Plastic Surgery is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-620b4cc640852c0718446e2b38feebdc7240b334184b755c66c99340856a23a03</citedby><cites>FETCH-LOGICAL-c372t-620b4cc640852c0718446e2b38feebdc7240b334184b755c66c99340856a23a03</cites><orcidid>0000-0002-3223-4819</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30076447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freire dos Santos, Mário Jorge</creatorcontrib><creatorcontrib>Carvalho, Ricardo</creatorcontrib><creatorcontrib>Arnaut, Luis G.</creatorcontrib><title>Split-Face, Randomized, Placebo-Controlled, Double-Blind Study to Investigate Passive Versus Active Dermal Filler Administration</title><title>Aesthetic plastic surgery</title><addtitle>Aesth Plast Surg</addtitle><addtitle>Aesthetic Plast Surg</addtitle><description>Background
QueryHyaluronic acid (HA) is a large polymer increasingly used as dermal filler. HA does not permeate through healthy skin and is administered using various injection techniques. As HA procedures become more popular, the number of complications in facial rejuvenation procedures is likely to increase. Alternative methods may be necessary to satisfy the increasing demand for HA procedures. High-frequency high-intensity ultrasound is a painless and noninvasive method to deliver large molecules to the skin that is expected to deliver HA with visible results.
Objective
Assess facial rejuvenation with HA delivered with high-frequency high-intensity ultrasound.
Methods
Fifteen women (mean age 55) willing to participate in a randomized, double-blind, face-split trial with HA and placebo formulations in different sides of the face, were subject to five treatment sessions with high-frequency high-intensity ultrasound. Photographs taken before the procedure and after the last procedure were evaluated by a panel of five experts, blind to which side was treated with the HA or with the placebo.
Results
The expert panel identified a noticeable facial rejuvenation in the HA side relative to the placebo with a very statistically significant difference between the two sides (
p
< 0.0001).
Conclusions
Administration of HA with high-frequency high-intensity ultrasound is safe and leads to unambiguous facial rejuvenation.
Level of Evidence I
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</description><subject>Adult</subject><subject>Cosmetic Techniques</subject><subject>Dermal fillers</subject><subject>Dermal Fillers - administration & dosage</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Esthetics</subject><subject>Female</subject><subject>Humans</subject><subject>Hyaluronic Acid - administration & dosage</subject><subject>Injections, Subcutaneous</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Otorhinolaryngology</subject><subject>Patient Satisfaction - statistics & numerical data</subject><subject>Plastic Surgery</subject><subject>Rejuvenation - physiology</subject><subject>Risk Assessment</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><issn>0364-216X</issn><issn>1432-5241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kU9LHDEYxkOx6Gr9AL2UQC8eTJt_k8wct6vbCkKlVuktZDJZiWSSbZIR9NSP3gxrWyh4Cnnye573JQ8Abwn-QDCWHzPGVAiESYsIxS3qXoEF4YyihnKyBxaYCY4oET8OwGHO9xgTKiXfBwesugXncgF-XW-9K2itjT2F33QY4uie7HAKr3yV-ohWMZQUvZ-1szj13qJP3oUBXpdpeIQlwovwYHNxd7pYeKVzdg8W3tqUpwyXpsy3M5tG7eHa1ZgEl8Pogssl6eJieANeb7TP9vj5PAI36_Pvqy_o8uvni9XyEhkmaUGC4p4bIzhuG2qwJC3nwtKetRtr-8FIynHPGK96L5vGCGG6js200JRpzI7AyS53m-LPqS6sRpeN9V4HG6es6v8xiduOkIq-_w-9j1MKdbuZoqxrOj4Hkh1lUsw52Y3aJjfq9KgIVnM9alePqvWouR7VVc-75-SpH-3w1_GnjwrQHZDrU7iz6d_ol1N_A6HhmYI</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Freire dos Santos, Mário Jorge</creator><creator>Carvalho, Ricardo</creator><creator>Arnaut, Luis G.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3223-4819</orcidid></search><sort><creationdate>20181201</creationdate><title>Split-Face, Randomized, Placebo-Controlled, Double-Blind Study to Investigate Passive Versus Active Dermal Filler Administration</title><author>Freire dos Santos, Mário Jorge ; Carvalho, Ricardo ; Arnaut, Luis G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-620b4cc640852c0718446e2b38feebdc7240b334184b755c66c99340856a23a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Cosmetic Techniques</topic><topic>Dermal fillers</topic><topic>Dermal Fillers - administration & dosage</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Esthetics</topic><topic>Female</topic><topic>Humans</topic><topic>Hyaluronic Acid - administration & dosage</topic><topic>Injections, Subcutaneous</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Otorhinolaryngology</topic><topic>Patient Satisfaction - statistics & numerical data</topic><topic>Plastic Surgery</topic><topic>Rejuvenation - physiology</topic><topic>Risk Assessment</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Freire dos Santos, Mário Jorge</creatorcontrib><creatorcontrib>Carvalho, Ricardo</creatorcontrib><creatorcontrib>Arnaut, Luis G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Aesthetic plastic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freire dos Santos, Mário Jorge</au><au>Carvalho, Ricardo</au><au>Arnaut, Luis G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Split-Face, Randomized, Placebo-Controlled, Double-Blind Study to Investigate Passive Versus Active Dermal Filler Administration</atitle><jtitle>Aesthetic plastic surgery</jtitle><stitle>Aesth Plast Surg</stitle><addtitle>Aesthetic Plast Surg</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>42</volume><issue>6</issue><spage>1655</spage><epage>1663</epage><pages>1655-1663</pages><issn>0364-216X</issn><eissn>1432-5241</eissn><abstract>Background
QueryHyaluronic acid (HA) is a large polymer increasingly used as dermal filler. HA does not permeate through healthy skin and is administered using various injection techniques. As HA procedures become more popular, the number of complications in facial rejuvenation procedures is likely to increase. Alternative methods may be necessary to satisfy the increasing demand for HA procedures. High-frequency high-intensity ultrasound is a painless and noninvasive method to deliver large molecules to the skin that is expected to deliver HA with visible results.
Objective
Assess facial rejuvenation with HA delivered with high-frequency high-intensity ultrasound.
Methods
Fifteen women (mean age 55) willing to participate in a randomized, double-blind, face-split trial with HA and placebo formulations in different sides of the face, were subject to five treatment sessions with high-frequency high-intensity ultrasound. Photographs taken before the procedure and after the last procedure were evaluated by a panel of five experts, blind to which side was treated with the HA or with the placebo.
Results
The expert panel identified a noticeable facial rejuvenation in the HA side relative to the placebo with a very statistically significant difference between the two sides (
p
< 0.0001).
Conclusions
Administration of HA with high-frequency high-intensity ultrasound is safe and leads to unambiguous facial rejuvenation.
Level of Evidence I
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30076447</pmid><doi>10.1007/s00266-018-1208-9</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3223-4819</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-216X |
| ispartof | Aesthetic plastic surgery, 2018-12, Vol.42 (6), p.1655-1663 |
| issn | 0364-216X 1432-5241 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2083708911 |
| source | Springer Link |
| subjects | Adult Cosmetic Techniques Dermal fillers Dermal Fillers - administration & dosage Double-Blind Method Double-blind studies Esthetics Female Humans Hyaluronic Acid - administration & dosage Injections, Subcutaneous Male Medicine Medicine & Public Health Middle Aged Original Article Otorhinolaryngology Patient Satisfaction - statistics & numerical data Plastic Surgery Rejuvenation - physiology Risk Assessment Ultrasonic imaging Ultrasonography |
| title | Split-Face, Randomized, Placebo-Controlled, Double-Blind Study to Investigate Passive Versus Active Dermal Filler Administration |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T19%3A27%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Split-Face,%20Randomized,%20Placebo-Controlled,%20Double-Blind%20Study%20to%20Investigate%20Passive%20Versus%20Active%20Dermal%20Filler%20Administration&rft.jtitle=Aesthetic%20plastic%20surgery&rft.au=Freire%20dos%20Santos,%20M%C3%A1rio%20Jorge&rft.date=2018-12-01&rft.volume=42&rft.issue=6&rft.spage=1655&rft.epage=1663&rft.pages=1655-1663&rft.issn=0364-216X&rft.eissn=1432-5241&rft_id=info:doi/10.1007/s00266-018-1208-9&rft_dat=%3Cproquest_cross%3E2083708911%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c372t-620b4cc640852c0718446e2b38feebdc7240b334184b755c66c99340856a23a03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2082395940&rft_id=info:pmid/30076447&rfr_iscdi=true |