A case of immune-mediated encephalitis related to daclizumab therapy

This report will detail a case of immune-mediated encephalitis in the context of daclizumab therapy. Daclizumab is a humanised monoclonal antibody which, prior to its recent worldwide withdrawal due to safety concerns, was utilised as a disease-modifying therapy in relapsing-remitting multiple scler...

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Bibliographic Details
Published in:Multiple sclerosis 2019-04, Vol.25 (5), p.750-753
Main Authors: Devlin, Michael, Swayne, Andrew, Newman, Martin, O’Gorman, Cullen, Brown, Helen, Ong, Benjamin, Robertson, Thomas, Airey, Caroline, Blum, Stefan
Format: Article
Language:English
Subjects:
Adult
Antibodies, Monoclonal, Humanized - adverse effects
Antibodies, Monoclonal, Humanized - therapeutic use
Biopsy
Central nervous system
Central Nervous System - drug effects
Cerebrospinal fluid
Daclizumab - adverse effects
Daclizumab - therapeutic use
Encephalitis
Encephalitis - diagnosis
Encephalitis - drug therapy
Encephalitis - etiology
Humans
Immunoglobulin G - adverse effects
Immunoglobulin G - therapeutic use
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - therapeutic use
Immunotherapy
Male
Monoclonal antibodies
Multiple sclerosis
Neuroimaging
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Summary:This report will detail a case of immune-mediated encephalitis in the context of daclizumab therapy. Daclizumab is a humanised monoclonal antibody which, prior to its recent worldwide withdrawal due to safety concerns, was utilised as a disease-modifying therapy in relapsing-remitting multiple sclerosis. The withdrawal of this therapy was prompted by concerns over 12 cases of serious immune-mediated adverse reactions in the central nervous system. We report an additional case, including clinical data and results of neuroimaging, cerebrospinal fluid (CSF) examination and brain biopsy.
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458518792403