Association of G472A allele of membrane bound catechol-O-methyltransferase gene with chronic post-sternotomy pain

Chronic persistent surgical pain (CPSP) is a complex disease with strong genetic component. The studies on revealed association of mutations in membrane bound catechol- O -methyltransferase gene with CPSP were reported indifferent ethnic populations across the globe. We identify that one out of four...

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Bibliographic Details
Published in:General thoracic and cardiovascular surgery 2019-09, Vol.67 (9), p.806-810
Main Authors: Dharaniprasad, Goduguchintha, Samantaray, Aloka, Hanumantha Rao, Mangu, Chandra, Abha, Sarma, Potukuchi Venkata Gurunadha Krishna
Format: Article
Language:English
Subjects:
Adult
Alleles
Cardiac Surgery
Cardiology
Cardiovascular disease
Case Report
Catechol O-Methyltransferase - genetics
Chronic pain
Chronic Pain - genetics
Coronary vessels
Female
Genotype & phenotype
Humans
Male
Mastectomy
Medicine
Medicine & Public Health
Middle Aged
Mutation
Pain, Postoperative - genetics
Pain, Postoperative - therapy
Patients
Pilot Projects
Polymorphism
Questionnaires
Sequence Analysis, DNA
Sternotomy - adverse effects
Sternotomy - methods
Surgery
Surgical Oncology
Surveys and Questionnaires
Thoracic Surgery
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Summary:Chronic persistent surgical pain (CPSP) is a complex disease with strong genetic component. The studies on revealed association of mutations in membrane bound catechol- O -methyltransferase gene with CPSP were reported indifferent ethnic populations across the globe. We identify that one out of four patients who underwent sternotomy procedure showed CPSP even after 3 months of surgery. The Mb.COMT gene sequence analysis revealed of the four patients, three patients had no mutation in Mb.COMT gene, while in one patient exhibited G472A mutation. Interestingly, this patient showed CPSP even after 90 days of surgery. The magnitude of the CPSP was evaluated with pain questionnaires’ at the end of 3 months after discharge from the hospital. In this study 25% (1/4) showed presence G472A allele correlating with CPSP. Further the study suggested that evaluation of G472A allele of Mb.COMT gene in the patients undergoing sternotomy for monitoring pain in pre and post-surgical events.
ISSN:1863-6705
1863-6713
DOI:10.1007/s11748-018-0981-3