Shedding of BAFF/APRIL Receptors Controls B Cells

Proteolytic shedding of the receptors BCMA, TACI, and BAFFR reduces their cell-surface expression and ligand-mediated survival of B cell subsets. This shedding is executed by protease γ-secretase or by metalloproteases, and is partially dependent on ligand binding and receptor interactions. Shed rec...

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Bibliographic Details
Published in:Trends in immunology 2018-09, Vol.39 (9), p.673-676
Main Authors: Meinl, Edgar, Thaler, Franziska S., Lichtenthaler, Stefan F.
Format: Article
Language:English
Subjects:
Animals
APRIL protein
Autoimmunity
B-Cell Activation Factor Receptor - genetics
B-Cell Activation Factor Receptor - metabolism
B-Lymphocyte Subsets - cytology
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
B-Lymphocytes - cytology
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Biomarkers
BLyS protein
Bone marrow
Cell Differentiation - genetics
Cell Differentiation - immunology
Cell surface
Cell survival
Cell Survival - genetics
Cell Survival - immunology
Disease
Fluids
Humans
Ligands
Lupus
Lymphocyte Activation - genetics
Lymphocyte Activation - immunology
Lymphocyte receptors
Lymphocytes B
Lymphoma
Lymphopoiesis - genetics
Lymphopoiesis - immunology
Multiple myeloma
Multiple sclerosis
Plasma
Proteins
Proteolysis
Receptors
Secretase
Shedding
T cell receptors
Tumor Necrosis Factor Ligand Superfamily Member 13 - genetics
Tumor Necrosis Factor Ligand Superfamily Member 13 - metabolism
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Description
Summary:Proteolytic shedding of the receptors BCMA, TACI, and BAFFR reduces their cell-surface expression and ligand-mediated survival of B cell subsets. This shedding is executed by protease γ-secretase or by metalloproteases, and is partially dependent on ligand binding and receptor interactions. Shed receptors may serve as biomarkers for autoimmunity and lymphoma.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2018.07.002