Biologically-derived nanomaterials for targeted therapeutic delivery to the brain

Delivery of imaging agents and pharmaceutical payloads to the central nervous system (CNS) is essential for efficient diagnosis and treatment of brain diseases. However, therapeutic delivery is often restricted by the blood-brain barrier (BBB), which prevents transport of clinical compounds to their...

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Bibliographic Details
Published in:Science progress (1916) 2018-09, Vol.101 (3), p.273-292
Main Authors: CURLEY, STEPHANIE M., CADY, NATHANIEL C.
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biodegradability
Biodegradation
Blood-brain barrier
Blood-Brain Barrier - metabolism
Capillary Permeability
Central nervous system
Conjugation
Dendrimers
Dendrimers - chemistry
Dendrimers - pharmacokinetics
Dendrimers - therapeutic use
Diagnosis
Drug Liberation
Humans
Image processing
Liposomes
Medical diagnosis
Nanoconjugates - chemistry
Nanoconjugates - therapeutic use
Nanomaterials
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - therapeutic use
Nanotechnology
Neuroimaging
Payloads
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Summary:Delivery of imaging agents and pharmaceutical payloads to the central nervous system (CNS) is essential for efficient diagnosis and treatment of brain diseases. However, therapeutic delivery is often restricted by the blood-brain barrier (BBB), which prevents transport of clinical compounds to their region of interest. This review discusses the methods that have been used to avoid or overcome this barrier, presenting the use of biologically-derived nanomaterial systems as an efficient strategy for the diagnosis and treatment of CNS diseases. Biological nanomaterials have many advantages over synthetic systems, including being biodegradable, biocompatible, easily surface functionalised for conjugation of targeting moieties, and are often able to self-assemble. These abilities are discussed in relation to various systems, including liposomes, dendrimers, and viral nanoparticles.
ISSN:0036-8504
2047-7163
DOI:10.3184/003685018X15306123582346