Cunninghamella Bertholletiae Infection (Mucormycosis) in a Patient with Acute T-cell Lymphoblastic Leukemia

Cunninghamella spp. are unusual opportunistic pathogens that have been identified with increased frequency in immunocompromised patients. Clinical infection by this fungus is almost always devastating and usually fatal. Infections with this group of organisms have been seen most frequently in patien...

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Bibliographic Details
Published in:Leukemia & lymphoma 2004-03, Vol.45 (3), p.617-620
Main Authors: Ortín, X, Escoda, L, Llorente, A, Rodriguez, R, Martínez, S, Boixadera, J, Cabezudo, E, Ugarriza, A
Format: Article
Language:English
Subjects:
Acute T-cell leukemia
Adult
Candida
Cunninghamella
Cunninghamella - isolation & purification
Cunninghamella bertholletiae
Cunninghamella bertholletiae infection
Fatal Outcome
Humans
Leukemia-Lymphoma, Adult T-Cell - complications
Male
Mucormycosis
Mucormycosis - diagnosis
Mucormycosis - etiology
Multiple Organ Failure - microbiology
Opportunistic Infections - diagnosis
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Summary:Cunninghamella spp. are unusual opportunistic pathogens that have been identified with increased frequency in immunocompromised patients. Clinical infection by this fungus is almost always devastating and usually fatal. Infections with this group of organisms have been seen most frequently in patients with hematological malignancy. Here we report the case of a patient with acute leukemia who developed multiorganic failure as a consequence of hematological dissemination by Cunninghamella bertholletiae. The case highlights the mortality associated with this fungal infection in immunocompromised patients, confirms the risk factors associated with non-candida fungal infections and shows a clinical presentation mimicking myocardial infarct and cerebrovascular stroke.
ISSN:1042-8194
1029-2403
DOI:10.1080/1042819031000139693