Antinociceptive and hypnotic effects of Premna tomentosa L. (Verbenaceae) in experimental animals

Medicinal plants are believed to be an important source of new chemical substances with potential therapeutic effects. The research into plants with alleged folklore use as pain relievers should therefore be viewed as a fruitful and logical research strategy in the search of new analgesic drugs. In...

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Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2003-05, Vol.75 (2), p.261-264
Main Authors: Pandima Devi, K, Sreepriya, M, Devaki, T, Balakrishna, K
Format: Article
Language:English
Subjects:
Acetic Acid
Analgesics - pharmacology
Animals
Antinociceptive
Aspirin - pharmacology
Biological and medical sciences
CNS-depressant
General pharmacology
Hypnotic
Hypnotics and Sedatives - pharmacology
Male
Medical sciences
Motor Activity - drug effects
Pain - chemically induced
Pain - prevention & control
Pain Measurement - drug effects
Pentobarbital - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Premna tomentosa
Rats
Rats, Wistar
Reaction Time - drug effects
Sleep - drug effects
Time Factors
Verbenaceae
Verbenaceae - chemistry
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Summary:Medicinal plants are believed to be an important source of new chemical substances with potential therapeutic effects. The research into plants with alleged folklore use as pain relievers should therefore be viewed as a fruitful and logical research strategy in the search of new analgesic drugs. In the present inquiry, antinociceptive effects of Premna tomentosa (PT) leaf extract (in methanol) were explored in experimental animals by acetic acid-induced writhing, tail flick and tail clip tests. Oral administration of PT extract at different doses (100, 200, 400 and 500 mg/kg) led to significant antinociceptive effects. The extract was also tested for hypnotic effects. Treatment with extracts at different doses (100, 200, 400 and 500 mg/kg) decreased the locomotor activity and potentiated the pentobarbitone-induced sleep time. The responses were dose-dependent. On the basis of the present finding, we can conclude that PT possesses antinociceptive and hypnotic activities.
ISSN:0091-3057
1873-5177
DOI:10.1016/S0091-3057(03)00074-1