Can Kynurenine Pathway Tryptophan Metabolites Be Used to Monitor Cadmium Exposure?

Tests evaluated the potential utilization of data detailing urinary concentrations of tryptophan metabolites (e.g., kynurenine (KYN) and kynurenic acid (KYNA)) for the monitoring of cadmium exposures and the early detection of impacts from its action in the kidney. The project evaluated correlations...

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Bibliographic Details
Published in:Polish journal of environmental studies 2005-01, Vol.14 (2), p.209-209
Main Authors: Pawlak, D, Brzoska, M, Zwierz, K, Stypulkowska, A, Moniuszko-Jakoniuk, J
Format: Article
Language:English
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Summary:Tests evaluated the potential utilization of data detailing urinary concentrations of tryptophan metabolites (e.g., kynurenine (KYN) and kynurenic acid (KYNA)) for the monitoring of cadmium exposures and the early detection of impacts from its action in the kidney. The project evaluated correlations between urinary excretion of both KYN and KYNA, Cd concentration, and the activity of isoenzyme B of N-acetyl- -D-glucosaminidase, which is considered one of the most sensitive indicators of Cd nephrotoxicity. Experiments were conducted on rats using an experimental model that corresponded to human environmental and occupational exposures to Cd. Exposed rats were administered 5 and 50 mg Cd/l in drinking water for a period of 24 weeks. Benefits of the proposed indicator regime are detailed.
ISSN:1230-1485