Effects of co-administration of tea epigallocatechin-3-gallate (EGCG) and caffeine on absorption and metabolism of EGCG in humans

Based on the ratios of (−)-epigallocatechin-3-gallate (EGCG) and caffeine (CAF) levels found in commercial tea drinks, EGCG and CAF were co-administered to human volunteers at various EGCG/CAF ratios, and plasma EGCG was determined by high performance liquid chromatography with chemiluminescence det...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2009-09, Vol.73 (9), p.2014-2017
Main Authors: Nakagawa, K.(Tohoku Univ., Sendai (Japan)), Nakayama, K, Nakamura, M, Sookwong, P, Tsuduki, T, Niino, H, Kimura, F, Miyazawa, T
Format: Article
Language:English
Subjects:
ABSORCION
ABSORPTION
Adult
BEBIDAS
BEVERAGES
Biological and medical sciences
BOISSON
CAFEINA
CAFEINE
CAFFEINE
Caffeine - administration & dosage
Caffeine - blood
CAMELIA SINENSIS
CAMELLIA SINENSIS
CATECHIN
Catechin - administration & dosage
Catechin - analogs & derivatives
Catechin - blood
Catechin - pharmacokinetics
CATECHINE
CATEQUINA
Chromatography, High Pressure Liquid
Fundamental and applied biological sciences. Psychology
GENERO HUMANO
GENRE HUMAIN
human plasma
Humans
Luminescence
MANKIND
METABOLISM
METABOLISME
METABOLISMO
Spectrophotometry, Ultraviolet
Tea - chemistry
tea catechins
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Summary:Based on the ratios of (−)-epigallocatechin-3-gallate (EGCG) and caffeine (CAF) levels found in commercial tea drinks, EGCG and CAF were co-administered to human volunteers at various EGCG/CAF ratios, and plasma EGCG was determined by high performance liquid chromatography with chemiluminescence detection. As for the results, in plasma taken after ingestion of a beverage containing 95 mg of EGCG alone, the area under the plasma EGCG concentration-time curve (AUC) was 857 ng·h/ml. A higher AUC (1,370 ng·h/ml) was observed when subjects ingested a beverage containing EGCG (95 mg) and a low amount of CAF (40 mg). In the case of ingestion of a beverage containing EGCG (95 mg) and a high amount of CAF (180 mg), the AUC tended to be somewhat higher (1,165 ng·h/ml), but not significantly so, compared with the beverage with EGCG alone. These findings (modulation of plasma EGCG level by CAF) provide ideas for modulating the bioavailability of tea catechins, which can be applied to tea-related drinks and foods.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.90195