The effects of high-frequency transcranial random noise stimulation (hf-tRNS) on global motion processing: An equivalent noise approach

• Published in: Brain stimulation 2018-11, Vol.11 (6), p.1263-1275
• Main Authors: Ghin, Filippo, Pavan, Andrea, Contillo, Adriano, Mather, George
• Format: Article
• Language: English
• Subjects: Adult; Directional tuning; Female; Global motion; Global sampling; High-frequency transcranial random noise stimulation; Humans; Internal noise; Male; Motion Perception - physiology; Photic Stimulation - methods; Psychomotor Performance - physiology; Transcranial Direct Current Stimulation - methods
• ISSN: 1935-861X; 1876-4754
• DOI: 10.1016/j.brs.2018.07.048

High frequency transcranial random noise stimulation (hf-tRNS) facilitates performance in several perceptual and cognitive tasks, however, little is known about the underlying modulatory mechanisms. In this study we compared the effects of hf-tRNS to those of anodal and cathodal tDCS in a global motion direction discrimination task. An equivalent noise (EN) paradigm was used to assess how hf-tRNS modulates the mechanisms underlying local and global motion processing. Motion coherence threshold and slope of the psychometric function were estimated using an 8AFC task in which observers had to discriminate the motion direction of a random dot kinematogram presented either in the left or right visual hemi-field. During the task hf-tRNS, anodal and cathodal tDCS were delivered over the left hMT+. In a subsequent experiment we implemented an EN paradigm in order to investigate the effects of hf-tRNS on the mechanisms involved in visual motion integration (i.e., internal noise and sampling). hf-tRNS reduced the motion coherence threshold but did not affect the slope of the psychometric function, suggesting no modulation of stimulus discriminability. Anodal and cathodal tDCS did not produce any modulatory effects. EN analysis in the last experiment found that hf-tRNS modulates sampling but not internal noise, suggesting that hf-tRNS modulates the integration of local motion cues. hf-tRNS interacts with the output neurons tuned to directions near to the directional signal, incrementing the signal-to-noise ratio and the pooling of local motion cues and thus increasing the sensitivity for global moving stimuli. •hf-tRNS, anodal and cathodal tDCS were compared on a global motion perception task.•hf-tRNS enhanced sensitivity (low coherence threshold) for global moving stimuli.•hf-tRNS was tested for motion integration mechanisms: internal noise and sampling.•hf-tRNS increased sampling but did not modulate internal noise.•hf-tRNS favours integration of local motion cues increasing motion sensitivity.